Intermediates

4-Pyridinylboronic Acid

  • CAS No.1692-15-5
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Pyridinylboronic Acid (CAS 1692-15-5) designed for advanced pharmaceutical intermediate synthesis and organic cross-coupling reactions.

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Product Technical Details

Product Overview

4-Pyridinylboronic Acid is a critical organic building block extensively utilized in modern medicinal chemistry and advanced material science. As a versatile heterocyclic boronic acid derivative, this compound serves as an essential reagent for palladium-catalyzed cross-coupling reactions, most notably the Suzuki-Miyaura coupling. Our manufacturing process ensures exceptional batch-to-batch consistency, making it the preferred choice for research laboratories and industrial-scale pharmaceutical production facilities worldwide.

The molecular structure features a pyridine ring substituted with a boronic acid group at the fourth position, providing unique electronic properties that facilitate efficient carbon-carbon bond formation. This chemical is indispensable for synthesizing complex biaryl structures found in numerous active pharmaceutical ingredients (APIs) and agrochemical compounds. We adhere to strict quality management systems to guarantee that every shipment meets the highest standards of chemical purity and performance.

Technical Specifications

ParameterSpecification
CAS Number1692-15-5
Molecular FormulaC5H6BNO2
Molecular Weight122.92 g/mol
AppearanceWhite powder
Assay (Purity)≥98.0%
Water Content≤0.50%
Melting Point>300 °C
Density1.23 g/cm3
Boiling Point330.7 °C at 760 mmHg

Industrial Applications

The primary application of 4-Pyridinylboronic Acid lies in the construction of sophisticated molecular architectures required for drug discovery and development. It acts as a key nucleophilic partner in cross-coupling reactions, enabling chemists to introduce pyridine motifs into target molecules with high regioselectivity. Beyond pharmaceuticals, this intermediate is valuable in the synthesis of liquid crystals, organic light-emitting diodes (OLEDs), and specialized polymers.

  • Essential reagent for Suzuki-Miyaura cross-coupling reactions.
  • Used in the synthesis of kinase inhibitors and antiviral agents.
  • Applied in agrochemical development for crop protection solutions.
  • Utilized in material science for functional organic electronics.
  • Supports custom synthesis projects requiring heterocyclic building blocks.

Quality Assurance and Packaging

Quality control is paramount in our production facility. Each batch of 4-Pyridinylboronic Acid undergoes rigorous analytical testing using high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy to verify identity and purity. A comprehensive Certificate of Analysis (COA) is provided with every order, detailing all test results against specified parameters. We understand the importance of supply chain reliability and maintain robust inventory levels to support urgent project timelines.

Standard packaging consists of 25kg fiber drums lined with polyethylene bags to ensure protection against moisture and contamination. Custom packaging solutions are available upon request to accommodate specific logistical requirements or smaller-scale research needs. Our logistics team coordinates global shipping, ensuring safe and timely delivery while complying with all international transport regulations.

Storage and Handling

To maintain optimal stability, 4-Pyridinylboronic Acid should be stored in a cool, dry, and well-ventilated area. Containers must remain tightly closed when not in use to prevent exposure to atmospheric moisture, which can lead to hydrolysis of the boronic acid group. Although classified as non-dangerous goods for transport, standard chemical hygiene practices should be followed during handling. Personnel are advised to use appropriate personal protective equipment, including gloves and safety goggles, to avoid skin or eye contact. In case of spills, standard absorbent materials should be used for cleanup.