Intermediates

4-(Trifluoromethoxy)benzaldehyde

  • CAS No.659-28-9
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-(Trifluoromethoxy)benzaldehyde (CAS 659-28-9) is a vital fluorinated building block for pharmaceutical and agrochemical synthesis, available in bulk quantities.

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Product Technical Details

Product Overview

4-(Trifluoromethoxy)benzaldehyde is a specialized fluorinated organic compound that serves as a critical intermediate in the synthesis of complex pharmaceutical agents and agrochemical products. Characterized by the presence of a trifluoromethoxy group attached to the para position of the benzaldehyde ring, this chemical building block offers unique electronic and steric properties that are highly valued in modern medicinal chemistry. Our manufacturing process ensures consistent quality and high purity levels, making it an ideal choice for research and industrial scale production.

The incorporation of fluorine atoms into organic molecules is a strategic approach to enhance metabolic stability, lipophilicity, and bioavailability. As a trusted global manufacturer, we provide this essential reagent with full technical support and documentation to facilitate your synthesis workflows.

Key Specifications

ParameterSpecification
Chemical Name4-(Trifluoromethoxy)benzaldehyde
CAS Number659-28-9
Molecular FormulaC8H5F3O2
Molecular Weight190.12 g/mol
AppearanceColorless to yellow liquid
Purity (GC)≥99.0%
Density1.331 g/cm3
Boiling Point93oC
Refractive Index1.458

Industrial Applications

This fluorinated aldehyde is extensively utilized as a key starting material in the preparation of various bioactive compounds. The trifluoromethoxy moiety is particularly useful in drug discovery programs where modulation of physicochemical properties is required without significantly increasing molecular weight. Common application areas include:

  • Pharmaceutical Intermediate: Used in the synthesis of kinase inhibitors and receptor modulators.
  • Agrochemical Synthesis: Serves as a precursor for novel herbicides and fungicides.
  • Material Science: Employed in the development of specialized polymers and liquid crystals.
  • Organic Synthesis: Acts as a versatile electrophile in condensation and reduction reactions.

Quality Assurance and Handling

We adhere to strict quality control protocols to ensure that every batch meets the specified purity standards. Each shipment is accompanied by a Certificate of Analysis (COA) detailing the results of our comprehensive testing procedures. Proper handling is essential to maintain the integrity of the product. It should be stored in a cool, ventilated area away from incompatible materials such as strong oxidizing agents.

Our packaging options are designed to ensure safety during transit, typically supplied in 25 kg drums, though custom packaging solutions are available upon request to meet specific logistical requirements. For large volume orders or technical inquiries regarding synthesis routes, our sales team is ready to provide competitive bulk pricing and detailed manufacturing process information.