Intermediates

4-Trifluoromethoxyphenylboronic Acid

  • CAS No.139301-27-2
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Trifluoromethoxyphenylboronic Acid (CAS 139301-27-2) designed for advanced pharmaceutical and OLED synthesis. Reliable supply with full COA support.

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Product Technical Details

Product Overview

4-Trifluoromethoxyphenylboronic Acid is a highly specialized organoboron compound that serves as a critical building block in modern organic synthesis. Characterized by the presence of a trifluoromethoxy group on the phenyl ring, this chemical exhibits unique electronic and steric properties that make it indispensable for cross-coupling reactions. Our manufacturing process ensures exceptional stability and reactivity, catering to the rigorous demands of research and industrial production environments.

As a leading global manufacturer, we prioritize consistency and quality in every batch. This boronic acid derivative is widely recognized for its utility in constructing complex molecular architectures, particularly within the pharmaceutical and materials science sectors. The introduction of the trifluoromethoxy moiety often enhances metabolic stability and lipophilicity in final drug candidates, making this intermediate a valuable asset for medicinal chemistry programs.

Technical Specifications

ParameterSpecification
Product Name4-Trifluoromethoxyphenylboronic Acid
CAS Number139301-27-2
Molecular FormulaC7H6BF3O3
Molecular Weight205.93 g/mol
AppearanceWhite to beige crystalline powder
Assay (Purity)≥98.0%
Water Content≤0.50%
Melting Point123-127 °C
Boiling Point256.6 °C at 760 mmHg
Density1.41 g/cm3
Refractive Index1.461
Transport ClassificationNot dangerous goods

Industrial Applications

This compound is primarily utilized as a key intermediate in the synthesis of advanced pharmaceutical agents. It plays a pivotal role in Suzuki-Miyaura coupling reactions, enabling the efficient formation of carbon-carbon bonds. Specific applications include the development of kinase inhibitors and hedgehog pathway modulators used in oncology research. Beyond pharmaceuticals, it is employed in the production of high-performance OLED materials and agrochemical formulations where specific electronic properties are required.

Our clients value this product for its reliability in multi-step synthesis routes. The high purity level minimizes side reactions, thereby improving overall yield and reducing downstream purification costs. Whether used in laboratory-scale discovery or large-scale commercial manufacturing, this boronic acid provides a robust foundation for chemical innovation.

Quality Assurance and Packaging

Quality control is integral to our operation. Each production batch undergoes rigorous testing using HPLC and NMR spectroscopy to verify identity and purity. We provide a comprehensive Certificate of Analysis (COA) with every shipment, ensuring full transparency and compliance with international standards. Our facility adheres to strict safety protocols to maintain product integrity from synthesis to delivery.

Standard packaging consists of 25kg drums, designed to protect the material from moisture and physical damage during transit. Custom packaging solutions are available upon request to meet specific logistical requirements. For storage, we recommend keeping the container tightly closed in a cool, dry, and well-ventilated area to preserve optimal chemical stability over extended periods.