4-(Trifluoromethyl)benzaldehyde
- CAS No.455-19-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4-(Trifluoromethyl)benzaldehyde (CAS 455-19-6) supplied for advanced organic synthesis. Reliable bulk manufacturer ensuring ≥99.0% GC purity for pharmaceutical and agrochemical intermediates.
Request Bulk PricingProduct Technical Details
Product Overview
4-(Trifluoromethyl)benzaldehyde is a premier fluorinated aromatic building block extensively utilized in the synthesis of complex pharmaceutical agents and agrochemical compounds. Identified by CAS Number 455-19-6, this organic intermediate features a benzaldehyde core substituted with a strongly electron-withdrawing trifluoromethyl group at the para position. This specific structural configuration imparts unique chemical reactivity and enhanced metabolic stability to downstream molecules, making it a critical component in modern medicinal chemistry and material science applications.
Our manufacturing facility produces this compound under strict quality control protocols to ensure consistent batch-to-batch reliability. The introduction of the trifluoromethyl moiety significantly influences the lipophilicity and bioavailability of final drug candidates, which is why high-purity grades are essential for research and development pipelines. We specialize in supplying bulk quantities to global partners who require dependable sources for their synthetic routes.
Technical Specifications
To guarantee performance in sensitive synthetic reactions, we adhere to rigorous analytical standards. The following table outlines the key physical and chemical properties of our standard grade product. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) verifying these parameters.
| CAS Number | 455-19-6 |
|---|---|
| Molecular Formula | C8H5F3O |
| Molecular Weight | 174.12 g/mol |
| Appearance | Colorless to light yellow liquid |
| Purity (GC) | ≥99.0% |
| Boiling Point | 66-67°C |
| Melting Point | 1-2°C |
| Density | 1.275 g/cm³ |
| Refractive Index | 1.463 |
Industrial Applications
The primary utility of 4-(Trifluoromethyl)benzaldehyde lies in its role as a versatile intermediate for organic synthesis. It serves as a key starting material for the production of various heterocyclic compounds, including imidazoles, pyrazoles, and quinolines, which are foundational structures in many therapeutic drugs. The electron-deficient nature of the carbonyl carbon, enhanced by the para-trifluoromethyl group, facilitates nucleophilic addition reactions such as reductive amination and Grignard additions.
Beyond pharmaceuticals, this chemical is employed in the agrochemical sector for developing herbicides and fungicides where fluorine substitution improves environmental persistence and biological activity. Additionally, it finds applications in the synthesis of liquid crystals and specialty polymers where specific dielectric properties are required. Our team works closely with clients to optimize supply chains for these diverse industrial uses.
Quality Assurance and Storage
We understand that impurities can derail complex synthetic pathways. Therefore, our production process involves advanced purification techniques to minimize side products and residual solvents. Quality assurance tests include Gas Chromatography (GC), Nuclear Magnetic Resonance (NMR), and moisture analysis to confirm compliance with specifications. We maintain full traceability for all manufactured batches.
For optimal stability, 4-(Trifluoromethyl)benzaldehyde should be stored in a cool, ventilated area away from direct sunlight and sources of ignition. The product is packaged in 200 kg drums or according to specific customer requirements to ensure safety during transit. Proper handling procedures should be followed to prevent oxidation or contamination. Contact our sales team for detailed safety data sheets and bulk pricing information tailored to your project needs.
