Intermediates

[4-(trifluoromethyl)phenyl]methanol

  • CAS No.349-95-1
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity [4-(trifluoromethyl)phenyl]methanol (CAS 349-95-1) designed for advanced organic synthesis and pharmaceutical intermediate applications.

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Product Technical Details

Product Overview

[4-(trifluoromethyl)phenyl]methanol, frequently recognized by its synonym 4-trifluoromethylbenzyl alcohol, stands as a pivotal fluorinated intermediate within the realm of advanced organic synthesis. This aromatic alcohol features a trifluoromethyl group attached to the para position of the benzyl ring, imparting unique physicochemical properties that are highly sought after in medicinal chemistry and material science. The presence of the trifluoromethyl moiety significantly enhances lipophilicity and metabolic stability, making this compound an essential building block for the development of novel pharmaceutical agents and agrochemical formulations. Our facility produces this chemical under strict quality control standards to ensure consistent performance in downstream reactions.

As a leading global manufacturer, we understand the critical role of high-purity intermediates in reducing synthesis steps and improving overall yield. The molecular structure of this compound allows for versatile functionalization, enabling chemists to explore diverse chemical spaces during drug discovery campaigns. Whether utilized in cross-coupling reactions or as a precursor for more complex heterocyclic systems, [4-(trifluoromethyl)phenyl]methanol delivers reliable results. We commit to supplying material that meets rigorous international specifications, supporting our partners in accelerating their research and development timelines.

Technical Specifications

ParameterValue
CAS Number349-95-1
Molecular FormulaC8H7F3O
Molecular Weight176.14 g/mol
AppearanceWhite Low melting solid
Assay (Purity)≥98.0%
Moisture Content≤0.2%
Melting Point22-25°C
Boiling Point78-80°C
Density1.286 g/cm3
Refractive Index1.459

Industrial Applications

The primary application of [4-(trifluoromethyl)phenyl]methanol lies in the synthesis of pharmaceutical active ingredients. The trifluoromethyl group is a privileged structure in modern drug design, often used to modulate the binding affinity of drug candidates to biological targets. Consequently, this intermediate is frequently employed in the production of kinase inhibitors, GPCR modulators, and other therapeutic classes. Beyond pharmaceuticals, it serves as a valuable component in the agrochemical sector, contributing to the efficacy of herbicides and pesticides by enhancing their environmental stability and penetration capabilities.

In addition to life sciences, this chemical finds utility in the materials industry. It can be incorporated into liquid crystals and polymers where specific electronic properties are required. The high purity level we maintain ensures that side reactions are minimized, which is crucial when scaling up processes from laboratory to industrial production. Our technical team provides comprehensive support to help clients integrate this building block into their specific synthesis routes effectively.

Quality Assurance and Handling

Quality is the cornerstone of our manufacturing process. Every batch of [4-(trifluoromethyl)phenyl]methanol undergoes thorough analytical testing using advanced chromatography and spectroscopy methods. We provide a Certificate of Analysis (COA) with every shipment, detailing the exact composition and purity profile. This transparency allows our clients to maintain their own quality standards without additional verification burdens. Our production facilities adhere to strict safety and environmental protocols, ensuring sustainable manufacturing practices.

Proper storage is essential to maintain the integrity of this chemical. We recommend storing the product in a cool, ventilated place away from direct sunlight and moisture. The standard packaging consists of 25 kg drums, which are designed to protect the contents during transit. However, we offer flexible packaging solutions to meet specific customer requirements, including smaller quantities for research purposes. Safety data sheets are available upon request, outlining proper handling procedures and emergency measures. By choosing our products, you gain access to a reliable supply chain backed by two decades of industry expertise.