4-(Trifluoromethylthio)bromobenzene
- CAS No.333-47-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4-(Trifluoromethylthio)bromobenzene (CAS 333-47-1), a versatile fluorinated aromatic intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
4-(Trifluoromethylthio)bromobenzene is a high-value fluorinated aromatic building block widely employed as a key intermediate in modern organic synthesis. With its unique combination of bromine and trifluoromethylthio functional groups, this compound serves as a critical precursor in the development of complex molecules for pharmaceuticals, crop protection agents, and specialty materials. Its reactivity profile enables diverse transformations, including cross-coupling reactions, nucleophilic substitutions, and heterocycle formations.
Specifications
| Molecular Formula | C₇H₄BrF₃S |
|---|---|
| Molecular Weight | 257.071 g/mol |
| CAS Number | 333-47-1 |
| Appearance | Colorless to light yellow transparent liquid |
| Assay | ≥98.0% |
| Density | 1.7 ± 0.1 g/cm³ |
| Boiling Point | 164.9 ± 40.0 °C at 760 mmHg |
| Flash Point | 53.5 ± 27.3 °C |
| Vapour Pressure | 2.5 ± 0.3 mmHg at 25°C |
| Refractive Index | 1.547 |
Industrial Applications
This fluorinated aryl bromide is primarily utilized as a synthetic intermediate in multi-step organic routes. Its applications include:
- Serving as a substrate in palladium-catalyzed Suzuki, Stille, and Negishi cross-coupling reactions.
- Enabling the introduction of the SCF₃ moiety—a highly lipophilic and metabolically stable group—into bioactive molecule scaffolds.
- Facilitating the construction of novel heterocyclic systems for drug discovery programs.
- Supporting agrochemical innovation through the synthesis of next-generation active ingredients.
Stored in a cool, well-ventilated area away from incompatible materials, 4-(Trifluoromethylthio)bromobenzene is typically supplied in 200 kg drums or customized packaging to meet global regulatory and logistical requirements.
