4,4,5,5,5-Pentafluoro-1-pentanol
- CAS No.148043-73-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4,4,5,5,5-Pentafluoro-1-pentanol (CAS 148043-73-6) is a valuable fluorinated intermediate for pharmaceutical and agrochemical R&D.
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Product Overview
4,4,5,5,5-Pentafluoro-1-pentanol (CAS 148043-73-6) is a specialty fluorinated alcohol widely employed as a key building block in advanced organic synthesis. With its unique perfluorinated alkyl chain and terminal hydroxyl functionality, this compound serves as a critical intermediate in the development of complex pharmaceutical APIs and novel agrochemical agents. Its high fluorine content imparts enhanced metabolic stability, lipophilicity, and bioavailability to downstream molecules, making it indispensable in modern medicinal chemistry workflows.
Specifications
| Molecular Formula | C5H7F5O |
|---|---|
| Molecular Weight | 178.10 g/mol |
| Assay | ≥98% |
| Total Impurity | ≤2.0% |
| Density | 1.350 g/cm³ |
| Boiling Point | 62–64 °C |
| Melting Point | 236 °C |
| Refractive Index | 1.327 |
Industrial Applications
This fluorinated intermediate is primarily utilized in the synthesis of more complex fluorinated derivatives, such as 4,4,5,5,5-pentafluoro-1-pentanethiol, through well-established functional group transformations. It plays a strategic role in multi-step synthetic routes targeting advanced therapeutic candidates, including steroidal antiestrogens used in oncology research. The molecule can be prepared via radical addition of pentafluoroiodoethane to allyl alcohol, followed by dehalogenation under reducing conditions—a scalable and robust industrial process.
As part of a comprehensive fluorochemical portfolio, 4,4,5,5,5-pentafluoro-1-pentanol supports innovation across multiple sectors:
- Pharmaceutical R&D: Enables synthesis of fluorine-containing drug candidates with improved pharmacokinetic profiles.
- Agrochemical Development: Serves as a precursor for next-generation pesticides with enhanced environmental stability.
- Advanced Materials: Contributes to the design of fluoropolymers and surface modifiers with low surface energy.
Manufactured under stringent quality control protocols, our product meets global standards for purity and consistency, ensuring reliable performance in sensitive synthetic applications.
