5-(2-Fluorophenyl)-1H-pyrrole-3-carbonitrile
- CAS No.1240948-77-9
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 5-(2-Fluorophenyl)-1H-pyrrole-3-carbonitrile (CAS 1240948-77-9) designed for pharmaceutical synthesis, specifically for Vonoprazan fumarate production with guaranteed quality and global supply.
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Product Overview
5-(2-Fluorophenyl)-1H-pyrrole-3-carbonitrile is a specialized organic compound characterized by its pyrrole core substituted with a fluorophenyl group and a nitrile functionality. This molecule serves as a critical building block in the modern pharmaceutical industry, particularly within the synthesis of advanced acid-suppressing agents. Our manufacturing process ensures exceptional chemical stability and reproducibility, making it an ideal choice for large-scale production environments where consistency is paramount.
The structural integrity of this intermediate allows for efficient downstream reactions, facilitating the construction of complex therapeutic molecules. As a key precursor, it plays an indispensable role in the development of potassium-competitive acid blockers. Our facility adheres to rigorous international standards to deliver material that meets the demanding specifications required by pharmaceutical formulators and research institutions worldwide.
Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 1240948-77-9 |
| Molecular Formula | C11H7FN2 |
| Molecular Weight | 186.19 g/mol |
| Appearance | Off-white to white powder |
| Purity | ≥99.0% |
| Water Content | ≤0.5% |
| Sulfated Ash | ≤0.1% |
| Total Impurity | ≤0.5% |
| Boiling Point | 364.6±32.0 °C at 760 mmHg |
| Density | 1.3±0.1 g/cm3 |
Industrial Applications
The primary application of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbonitrile lies in the synthesis of Vonoprazan fumarate, a novel medication used for the treatment of acid-related disorders. The high purity level of our intermediate ensures optimal reaction yields and minimizes the formation of unwanted by-products during the coupling stages. This efficiency is crucial for maintaining cost-effectiveness and regulatory compliance in final drug product manufacturing.
- Essential intermediate for Vonoprazan fumarate synthesis.
- Suitable for diverse organic synthesis pathways involving pyrrole derivatives.
- Compatible with standard pharmaceutical manufacturing processes.
- Supports research and development of new gastrointestinal therapeutics.
- Ensures high conversion rates in downstream chemical reactions.
Quality Assurance and Storage
Quality control is the cornerstone of our production philosophy. Each batch of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbonitrile undergoes comprehensive testing using advanced analytical techniques such as High-Performance Liquid Chromatography (HPLC) and Nuclear Magnetic Resonance (NMR) spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, verifying that all physical and chemical parameters meet or exceed the stated specifications.
To maintain product stability, proper storage conditions are essential. The material should be kept in a tightly closed container within a cool, dry, and well-ventilated area, ideally at temperatures between 2°C and 8°C. It must be stored away from incompatible substances to prevent degradation. Our packaging options include 25kg cardboard drums or custom configurations based on specific customer requirements, ensuring safe transit and handling across global logistics networks.
