5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde
- CAS No.881674-56-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde (CAS 881674-56-2) designed for pharmaceutical synthesis. Ideal intermediate for Vonoprazan production with strict quality control.
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Product Overview
5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde is a specialized heterocyclic compound serving as a critical building block in modern medicinal chemistry. Characterized by its fluorophenyl substitution on the pyrrole ring, this molecule offers unique reactivity profiles essential for constructing complex pharmaceutical architectures. Our manufacturing process ensures exceptional batch-to-batch consistency, making it a reliable choice for large-scale API synthesis.
This compound is particularly valued in the development of potassium-competitive acid blockers. The presence of the fluorine atom enhances metabolic stability and binding affinity in downstream drug candidates. We adhere to rigorous quality standards to support our partners in achieving regulatory compliance for their final drug products.
Key Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | 5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde |
| CAS Number | 881674-56-2 |
| Molecular Formula | C11H8FNO |
| Molecular Weight | 189.19 g/mol |
| Appearance | White powder |
| Purity | ≥99.0% |
| Water Content | ≤0.5% |
| Sulfated Ash | ≤0.1% |
| Total Impurity | ≤0.5% |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 370.6±32.0 °C at 760 mmHg |
Industrial Applications
The primary application of this intermediate is in the synthesis of Vonoprazan fumarate, a groundbreaking therapy for acid-related disorders. Its high purity profile minimizes the formation of difficult-to-remove byproducts during subsequent coupling reactions. Beyond this specific use, the compound serves as a versatile scaffold for developing novel pyrrole-based therapeutics targeting various neurological and gastrointestinal pathways.
Chemists utilize this aldehyde for condensation reactions, reductive amination, and heterocycle formation. The stability of the fluorophenyl group allows for harsh reaction conditions without degradation, providing flexibility in synthetic route design. Our technical team can assist in optimizing these processes for maximum yield and efficiency.
Quality Assurance and Packaging
Quality is paramount in pharmaceutical intermediate manufacturing. Each batch undergoes comprehensive analysis using HPLC, NMR, and MS to confirm identity and purity. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring full traceability and compliance with international standards.
- Packaged in 25kg cardboard drums or customized containers.
- Stored in tightly closed containers at 2°C to 8°C.
- Kept in a cool, dry, well-ventilated area away from incompatible substances.
- Global shipping capabilities with secure logistics partners.
We are committed to supporting your supply chain with reliable volumes and timely delivery. Contact our sales team for detailed technical data, pricing information, or custom synthesis requests tailored to your specific project requirements.
