5-(4-Bromophenyl)pyrimidine-4,6-diol
- CAS No.706811-25-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 5-(4-Bromophenyl)pyrimidine-4,6-diol (CAS 706811-25-8) designed for pharmaceutical synthesis. Reliable supply for macitentan intermediate production with strict quality control.
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Product Overview
5-(4-Bromophenyl)pyrimidine-4,6-diol is a specialized heterocyclic compound serving as a critical building block in modern pharmaceutical synthesis. Classified under advanced organic intermediates, this pyrimidine derivative plays an essential role in the production of active pharmaceutical ingredients (APIs), specifically within the endothelin receptor antagonist class. Our manufacturing process ensures consistent molecular integrity, making it an ideal choice for research and development teams focused on cardiovascular and pulmonary therapeutic solutions.
As a key precursor, this compound facilitates the construction of complex molecular architectures required for high-efficacy medications. The presence of the bromophenyl group enhances reactivity during coupling reactions, allowing chemists to achieve precise structural modifications. We prioritize stringent quality assurance protocols to guarantee that every batch meets the rigorous demands of global pharmaceutical standards.
Technical Specifications
Our production facility adheres to strict operational guidelines to maintain product stability and purity. The following table outlines the fundamental physical and chemical properties verified through advanced analytical methods such as HPLC and NMR spectroscopy.
| Parameter | Value |
|---|---|
| CAS Number | 706811-25-8 |
| Molecular Formula | C10H7BrN2O2 |
| Molecular Weight | 267.079 g/mol |
| Appearance | White powder |
| Assay (Purity) | ≥98.0% |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 429.6±45.0 °C at 760 mmHg |
| Flash Point | 213.6±28.7 °C |
Industrial Applications
The primary application of 5-(4-Bromophenyl)pyrimidine-4,6-diol lies in the synthesis of Macitentan, a potent dual endothelin receptor antagonist used in the management of pulmonary arterial hypertension. Beyond this specific API, the compound serves as a versatile intermediate for various heterocyclic synthesis routes. Its chemical structure allows for diverse functionalization, making it valuable for medicinal chemistry programs aiming to develop novel therapeutic agents.
Pharmaceutical manufacturers rely on this intermediate for its reproducibility and compatibility with standard organic synthesis protocols. Whether used in scale-up production or early-stage drug discovery, the material provides a reliable foundation for constructing complex drug molecules.
Quality Assurance and Packaging
We understand that purity and consistency are paramount in pharmaceutical manufacturing. Each production lot undergoes comprehensive testing to verify identity, assay, and impurity profiles. A Certificate of Analysis (COA) is provided with every shipment to ensure full transparency and compliance with client specifications.
- Strict quality control measures at every production stage
- Advanced analytical testing for purity verification
- Comprehensive documentation including COA and MSDS
- Custom packaging solutions available upon request
Standard packaging consists of 25 kg drums, designed to protect the material from moisture and light during transit. For larger volume requirements or specific logistical needs, we offer flexible packaging options tailored to customer requirements. Proper storage in a cool, ventilated area ensures the long-term stability of the product.
Why Choose Our Supply
As a global manufacturer with decades of experience in fine chemicals, we commit to delivering high-performance intermediates that support your innovation goals. Our supply chain is optimized for reliability, ensuring timely delivery without compromising on quality. Partner with us for a seamless procurement experience backed by technical expertise and competitive bulk pricing.
