5-Amino-1H-imidazole-4-carboxamide hydrochloride
- CAS No.72-40-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 5-Amino-1H-imidazole-4-carboxamide hydrochloride (CAS 72-40-2) designed for pharmaceutical synthesis. Ideal intermediate for anticancer drug manufacturing with strict quality control.
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Product Overview
5-Amino-1H-imidazole-4-carboxamide hydrochloride is a critical pharmaceutical intermediate widely recognized for its stability and reactivity in organic synthesis. Identified by CAS number 72-40-2, this compound features an imidazole core structure substituted with an amino group and a carboxamide functionality. It serves as a foundational building block in the production of complex therapeutic agents, particularly within the oncology sector. Our manufacturing process ensures consistent molecular integrity, making it a reliable choice for research and development teams as well as large-scale API production facilities.
The chemical is supplied as a white to gray-white crystalline powder, exhibiting excellent solubility characteristics in aqueous solutions. This physical property facilitates its integration into various reaction pathways without requiring extensive preprocessing. As a key precursor, it plays an indispensable role in the construction of heterocyclic systems found in modern medicinal chemistry.
Technical Specifications
Quality control is paramount in the supply of pharmaceutical intermediates. Each batch undergoes rigorous analytical testing to verify compliance with international standards. The following table outlines the key physical and chemical parameters guaranteed for this product:
| Parameter | Specification |
|---|---|
| Appearance | White or Gray-white powder |
| CAS Number | 72-40-2 |
| Molecular Formula | C4H7ClN4O |
| Molecular Weight | 162.578 |
| Melting Point | 249.5~252.5°C |
| Loss on Drying | ≤0.5% |
| Assay (Titration) | ≥98.5% |
| Purity (HPLC) | ≥99.0% |
| Heavy Metals | ≤20ppm |
Industrial Applications
The primary application of 5-Amino-1H-imidazole-4-carboxamide hydrochloride is in the synthesis of Temozolomide, a potent alkylating agent used in the treatment of specific brain tumors. Beyond this specific pathway, the compound is utilized in the development of novel nucleoside analogs and other heterocyclic pharmaceuticals. Its high purity profile minimizes side reactions during synthesis, thereby improving overall yield and reducing downstream purification costs.
Research institutions also utilize this material for mechanistic studies involving imidazole derivatives. The consistent quality provided by our facility supports both academic inquiry and commercial drug development pipelines. We recommend this material for processes requiring high fidelity in structural assembly and minimal impurity profiles.
Quality Assurance and Handling
We adhere to strict quality management systems to ensure product safety and reliability. Every shipment is accompanied by a Certificate of Analysis (COA) detailing batch-specific test results. Our packaging options include 25 kg drums, with customization available to meet specific logistical requirements. Proper storage is essential to maintain stability; the product should be kept in a cool, ventilated environment away from direct sunlight and moisture.
- Comprehensive quality testing including HPLC and titration.
- Secure packaging to prevent contamination during transit.
- Global shipping capabilities with documented supply chain integrity.
- Technical support available for synthesis optimization inquiries.
For bulk orders or custom synthesis requirements, our sales team is ready to provide competitive pricing and detailed logistical information. We are committed to supporting the pharmaceutical industry with high-quality intermediates that meet the demanding standards of modern drug manufacturing.
