5-Bromo-2,4-difluoroaniline
- CAS No.452-92-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 5-Bromo-2,4-difluoroaniline (CAS 452-92-6) designed for advanced organic synthesis. Reliable supply for pharmaceutical and agrochemical intermediate production.
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Product Overview
5-Bromo-2,4-difluoroaniline is a highly specialized fluorinated aromatic amine that serves as a critical building block in modern organic synthesis. Characterized by its unique substitution pattern featuring both bromine and fluorine atoms on the aniline ring, this compound offers exceptional reactivity for cross-coupling reactions and nucleophilic substitutions. Our manufacturing facility produces this intermediate under strict quality control standards to ensure consistency for downstream chemical processes.
The presence of fluorine atoms enhances the metabolic stability and lipophilicity of final molecules, making this intermediate particularly valuable in medicinal chemistry and agrochemical development. We prioritize safety and purity in every batch, providing a reliable source for research and industrial scale production.
Technical Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 5-Bromo-2,4-difluoroaniline |
| CAS Number | 452-92-6 |
| Molecular Formula | C6H4BrF2N |
| Molecular Weight | 208.00 g/mol |
| Appearance | Colorless liquid |
| Purity | ≥99.0% |
| Density | 1.212 g/cm3 |
| Melting Point | 25-29°C |
| Boiling Point | 158.1°C at 760 mmHg |
| Flash Point | 49.4°C |
| Refractive Index | 1.57 |
Industrial Applications
This fluorinated aniline derivative is extensively utilized as a key intermediate in the synthesis of complex pharmaceutical compounds. The bromine substituent allows for versatile palladium-catalyzed coupling reactions, while the fluorine atoms provide desirable physicochemical properties to the final active pharmaceutical ingredients. Beyond pharmaceuticals, it finds application in the development of advanced agrochemicals and functional materials where specific electronic properties are required.
Our clients leverage this building block for creating kinase inhibitors, receptor modulators, and other therapeutic agents. The high purity level ensures minimal side reactions during synthesis, optimizing yield and reducing purification costs in large-scale manufacturing environments.
Quality Assurance And Storage
Every production batch undergoes rigorous analytical testing including GC, HPLC, and NMR spectroscopy to verify identity and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment to guarantee compliance with specified standards. Proper handling is essential to maintain product integrity.
For storage, maintain the container tightly closed in a cool, dry, and well-ventilated area away from incompatible substances. The recommended storage temperature is between 2-8°C to prevent degradation. We offer flexible packaging options including 25kg drums to suit various logistical requirements. Our global distribution network ensures timely delivery while maintaining cold chain integrity where necessary.
