Intermediates

5-Bromo-2-chloro-3-nitropyridine

  • CAS No.67443-38-3
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 5-Bromo-2-chloro-3-nitropyridine (CAS 67443-38-3) designed for advanced organic synthesis. Reliable supply with strict quality control for pharmaceutical intermediates.

Request Bulk Pricing

Product Technical Details

Product Overview

5-Bromo-2-chloro-3-nitropyridine represents a significant advancement in available heterocyclic building blocks for the chemical industry. As a halogenated nitropyridine, it possesses distinct electronic properties that facilitate selective transformations. The electron-withdrawing nature of the nitro group activates the ring towards nucleophilic attack, while the halogen substituents allow for cross-coupling reactions such as Suzuki or Buchwald-Hartwig aminations. This dual functionality makes it an indispensable tool for medicinal chemists aiming to construct diverse chemical libraries.

In terms of physical characteristics, the compound presents as a yellow to light brown crystalline powder. This appearance is indicative of its high purity levels when manufactured correctly. The melting point range of 64-69°C allows for easy handling in various solvent systems. Our production process focuses on minimizing impurities that could interfere with downstream reactions, ensuring that the final synthetic products meet regulatory standards for pharmaceutical use.

Technical Specifications

Parameter Value
CAS Number 67443-38-3
Molecular Formula C5H2BrClN2O2
Molecular Weight 237.44 g/mol
Purity (GC) ≥99.0%
Appearance Yellow to light brown crystalline powder
Melting Point 64-69°C
Boiling Point 285.4°C
Moisture ≤0.5%

Industrial Applications

This pyridine derivative is extensively utilized in the development of active pharmaceutical ingredients (APIs). It acts as a key intermediate in the synthesis of kinase inhibitors and other therapeutic agents targeting various biological pathways. Additionally, it finds application in the agrochemical sector for creating novel pesticides and herbicides.

  • Pharmaceutical intermediate for drug discovery
  • Building block for heterocyclic chemistry
  • Reagent for nucleophilic aromatic substitution
  • Precursor for agrochemical formulations

Quality Assurance and Packaging

Quality assurance is the cornerstone of our supply chain. We understand that consistency in raw materials is vital for reproducible results in research and production. Therefore, every batch of 5-Bromo-2-chloro-3-nitropyridine is subjected to strict analytical testing. Parameters such as moisture content, which is kept below 0.5%, are closely monitored to prevent hydrolysis or degradation. We provide full documentation, including COA and MSDS, to support regulatory filings and quality audits.

Safe handling procedures should always be followed when working with this chemical. Although it is stable under recommended storage conditions, it should be kept in a cool, ventilated place away from incompatible substances. Personal protective equipment, including gloves and eye protection, is advised during handling. Our packaging options include standard 25 kg drums, which are designed to protect the material from moisture and physical damage during global shipping. We also offer flexible packaging solutions to accommodate specific customer needs, ensuring that the product arrives in optimal condition regardless of destination.