5-Bromo-2-Chloropyrimidine

Product Overview

5-Bromo-2-chloropyrimidine stands as a critical heterocyclic building block within the modern pharmaceutical landscape. This halogenated pyrimidine derivative is extensively utilized in the construction of complex organic molecules, serving as a foundational element for various active pharmaceutical ingredients. Our facility specializes in the production of this compound with a focus on exceptional purity and consistency, ensuring that downstream synthesis processes proceed without interruption or contamination issues.

As a dedicated manufacturer, we understand the rigorous demands of medicinal chemistry. Therefore, every batch of 5-Bromo-2-chloropyrimidine undergoes comprehensive analytical testing. We prioritize the stability of the halogen substituents, which are crucial for subsequent cross-coupling reactions and nucleophilic substitutions. Our commitment to quality ensures that researchers and production teams receive a material that meets the highest industry standards for synthetic versatility.

Technical Specifications

To guarantee performance in sensitive synthetic routes, we maintain strict control over impurities and physical parameters. The following table outlines the standard specification profile for our commercial grade material:

Physical and Chemical Properties

Understanding the physicochemical characteristics of 5-Bromo-2-chloropyrimidine is essential for safe handling and optimal reaction design. The compound typically presents as a crystalline solid with a melting point range between 76 and 81 degrees Celsius. Its density is approximately 1.86 g/cm3, indicating a compact molecular structure typical of halogenated heterocycles. The boiling point is recorded at 95 degrees Celsius under reduced pressure (15mm), which is a critical parameter for purification processes such as distillation.

Furthermore, the refractive index is measured at 1.588, providing a useful identifier for quality control verification. The flash point aligns with the boiling point conditions under vacuum, necessitating standard safety precautions during heating operations. These properties collectively define the handling profile, ensuring that chemists can integrate this intermediate safely into multi-step synthesis pathways without unexpected physical behaviors.

Industrial Applications

The primary application of this chemical lies in the synthesis of advanced therapeutic agents. Notably, it serves as a key intermediate in the production of Macitentan, an endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension. The specific arrangement of bromo and chloro substituents on the pyrimidine ring allows for selective functionalization, enabling chemists to build complex molecular architectures with high precision.

Beyond this specific application, the compound is valuable in agrochemical research and material science where pyrimidine cores are required. Its reactivity profile supports various catalytic processes, making it a versatile tool for process chemistry teams aiming to scale up production from laboratory to industrial levels. Our supply chain is optimized to support both R&D initiatives and large-scale manufacturing requirements.

Quality Assurance and Logistics

We employ a robust quality management system to ensure that every shipment meets the agreed-upon specifications. A Certificate of Analysis (COA) is provided with each batch, detailing the results of all critical quality attributes. Our packaging options include 25kg cardboard drums, designed to protect the material from moisture and light exposure during transit. Custom packaging solutions are available upon request to suit specific logistical needs.

Storage recommendations include keeping the container tightly closed in a cool, dry, and well-ventilated area. Protection from strong light and heat sources is essential to maintain chemical stability over extended periods. With our global distribution network, we ensure timely delivery to laboratories and production facilities worldwide, supporting your project timelines with reliability and professionalism.