5-Bromo-2-fluorobenzonitrile
- CAS No.179897-89-3
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 5-Bromo-2-fluorobenzonitrile (CAS 179897-89-3) is a key pharmaceutical intermediate used primarily in the synthesis of Febuxostat. We offer bulk quantities with strict quality control and global shipping capabilities.
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Product Overview
5-Bromo-2-fluorobenzonitrile is a specialized halogenated aromatic compound that serves as a critical building block in modern pharmaceutical synthesis. Characterized by its unique substitution pattern featuring both bromine and fluorine atoms on the benzene ring, this compound offers exceptional reactivity for cross-coupling reactions and nucleophilic substitutions. Our facility produces this intermediate under stringent quality management systems to ensure consistency and reliability for downstream drug manufacturing processes.
As a leading manufacturer in the fine chemicals sector, we understand the vital role this substance plays in the production of advanced therapeutic agents. The presence of the nitrile group combined with halogen substituents makes it an ideal precursor for constructing complex molecular architectures required in contemporary medicinal chemistry.
Technical Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 5-Bromo-2-fluorobenzonitrile |
| CAS Number | 179897-89-3 |
| Molecular Formula | C7H3BrFN |
| Molecular Weight | 200.008 g/mol |
| Appearance | White powder |
| Assay (Purity) | ≥98.0% |
| Melting Point | 76-81 °C |
| Boiling Point | 220.4±20.0 °C at 760 mmHg |
| Density | 1.7±0.1 g/cm3 |
| Flash Point | 87.1±21.8 °C |
Industrial Applications
The primary application of 5-Bromo-2-fluorobenzonitrile lies in the pharmaceutical industry, specifically as a key intermediate in the synthesis of Febuxostat. Febuxostat is a widely recognized non-purine selective inhibitor of xanthine oxidase used for the treatment of hyperuricemia in patients with gout. The high purity of our supplied intermediate ensures that the final active pharmaceutical ingredient meets rigorous regulatory standards for safety and efficacy.
Beyond this specific application, the compound is valuable in organic synthesis laboratories for developing new fluorinated compounds. The fluorine atom enhances metabolic stability and bioavailability in drug candidates, while the bromine atom provides a handle for palladium-catalyzed coupling reactions. This dual functionality makes it a versatile tool for research and development teams working on novel therapeutic pathways.
Quality Assurance and Safety
We adhere to international quality standards to guarantee the performance of our chemicals. Each batch undergoes comprehensive testing using advanced analytical techniques such as HPLC and GC-MS to verify purity and identify any impurities. A Certificate of Analysis (COA) is provided with every shipment to document compliance with specified parameters.
Regarding safety, this compound should be handled in accordance with standard laboratory safety protocols. It is recommended to store the material in a cool, ventilated place away from incompatible substances. Proper personal protective equipment, including gloves and eye protection, should be worn during handling to prevent exposure. Our packaging is designed to maintain integrity during transit, ensuring the product arrives in optimal condition.
Packaging and Logistics
Standard packaging consists of 25 kg drums, which are suitable for industrial-scale operations. However, we recognize that different clients have varying needs. Therefore, we offer flexible packaging solutions according to customer requirements. Our logistics network supports global shipping, ensuring timely delivery to manufacturers and research institutions worldwide. For bulk orders, competitive pricing is available, reflecting our commitment to supporting the pharmaceutical supply chain with cost-effective solutions.
