5-Bromo-2-fluorobenzotrifluoride
- CAS No.393-37-3
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 5-Bromo-2-fluorobenzotrifluoride (CAS 393-37-3) is a critical fluorinated building block designed for advanced pharmaceutical synthesis and agrochemical applications.
Request Bulk PricingProduct Technical Details
Product Overview
5-Bromo-2-fluorobenzotrifluoride is a highly specialized fluorinated aromatic compound that serves as an essential building block in modern organic synthesis. Characterized by its unique substitution pattern featuring both bromine and fluorine atoms on a benzotrifluoride core, this intermediate offers exceptional reactivity for cross-coupling reactions and nucleophilic substitutions. Our facility produces this chemical under strict quality control standards to ensure consistency for downstream pharmaceutical and agrochemical manufacturing processes.
The presence of the trifluoromethyl group significantly enhances the lipophilicity and metabolic stability of final drug candidates, making this intermediate particularly valuable in medicinal chemistry. The bromine atom provides a versatile handle for palladium-catalyzed coupling reactions, while the fluorine substituent influences the electronic properties of the aromatic ring. This combination allows chemists to construct complex molecular architectures with high precision and efficiency.
Key Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 5-Bromo-2-fluorobenzotrifluoride |
| CAS Number | 393-37-3 |
| Molecular Formula | C7H3BrF4 |
| Molecular Weight | 242.996 g/mol |
| Appearance | Colorless liquid |
| Purity | ≥98.0% |
| Density | 1.72 g/mL at 25 °C |
| Boiling Point | 179-180 °C at 50 mm Hg |
| Refractive Index | 1.462 |
Industrial Applications
This fluorinated intermediate is primarily utilized in the synthesis of active pharmaceutical ingredients (APIs) where fluorine substitution is required to improve bioavailability and binding affinity. It is frequently employed in the development of kinase inhibitors, anti-inflammatory agents, and central nervous system therapeutics. Beyond pharmaceuticals, this compound finds application in the agrochemical sector for producing herbicides and pesticides that require enhanced environmental stability.
Researchers also leverage this building block in material science for creating novel polymers and liquid crystals. The robust carbon-fluorine bonds contribute to the thermal and chemical stability of the resulting materials. Our global manufacturing network ensures that clients receive materials suitable for both laboratory-scale research and large-scale commercial production.
Quality Assurance and Packaging
We adhere to rigorous quality management systems to guarantee the integrity of every batch. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity levels, impurity profiles, and physical constants. Our production process utilizes advanced distillation and purification techniques to remove trace contaminants that could interfere with sensitive catalytic reactions.
Standard packaging consists of 25kg fiber drums designed to protect the contents from moisture and physical damage during transit. Custom packaging solutions are available upon request to meet specific logistical requirements. We maintain a robust supply chain to ensure timely delivery to laboratories and manufacturing plants worldwide.
Safety and Storage Guidelines
Proper handling procedures should be followed to ensure safety during use. This chemical should be stored in a tightly closed container within a cool, dry, and well-ventilated area away from incompatible substances. Personnel should wear appropriate personal protective equipment including chemical-resistant gloves and safety goggles when handling this material. In case of spills, standard chemical containment and cleanup protocols should be implemented immediately to prevent environmental contamination.
