5-Bromo-2-methylindole
- CAS No.1075-34-9
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 5-Bromo-2-methylindole (CAS 1075-34-9), a key building block for advanced organic synthesis and pharmaceutical intermediates.
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Product Overview
5-Bromo-2-methylindole is a high-value heterocyclic compound widely employed as a versatile intermediate in the synthesis of complex organic molecules. With its bromine substituent at the 5-position and a methyl group at the 2-position of the indole core, this molecule offers excellent regioselectivity for cross-coupling reactions, making it indispensable in medicinal chemistry and agrochemical research.
Specifications
| Molecular Formula | C9H8BrN |
|---|---|
| Molecular Weight | 210.070 g/mol |
| CAS Number | 1075-34-9 |
| Appearance | Light yellow crystalline powder |
| Assay | ≥98.0% |
| Moisture | ≤1.0% |
| Melting Point | 104–107 °C (lit.) |
| Boiling Point | 325.1 ± 22.0 °C at 760 mmHg |
| Density | 1.6 ± 0.1 g/cm³ |
| Flash Point | 150.4 ± 22.3 °C |
| Vapour Pressure | 0.0 ± 0.7 mmHg at 25 °C |
| Refractive Index | 1.685 |
Industrial Applications
This compound serves primarily as a critical intermediate in the development of active pharmaceutical ingredients (APIs), functional materials, and specialty agrochemicals. Its structural features enable efficient participation in Suzuki, Negishi, and other palladium-catalyzed coupling protocols, facilitating rapid molecular diversification.
- Ideal for constructing indole-based scaffolds in drug discovery programs
- Used in the synthesis of kinase inhibitors and receptor modulators
- Suitable for scale-up under GMP-compliant manufacturing conditions
Stored in a cool, dry, and well-ventilated area, 5-Bromo-2-methylindole maintains stability under recommended conditions. Standard packaging is 25 kg per drum, with custom options available to meet specific client requirements.
