5-Bromo-2-(Trifluoromethyl)Aniline
- CAS No.703-91-3
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 5-Bromo-2-(Trifluoromethyl)Aniline (CAS 703-91-3) designed for pharmaceutical intermediate synthesis. Available in bulk with strict quality control.
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Product Overview
5-Bromo-2-(Trifluoromethyl)Aniline is a highly specialized fluorinated aromatic amine that serves as a critical building block in modern medicinal chemistry and agrochemical development. This compound features a unique structural arrangement where a bromine atom and a trifluoromethyl group are positioned on the aniline ring, providing distinct electronic properties that are invaluable for complex organic synthesis. Our manufacturing process ensures consistent quality and high purity levels, making it an ideal choice for research and development teams focused on creating novel therapeutic agents.
The presence of the trifluoromethyl group significantly enhances the metabolic stability and lipophilicity of downstream drug candidates, while the bromo substituent offers a versatile handle for cross-coupling reactions such as Suzuki, Heck, or Buchwald-Hartwig aminations. This dual functionality allows chemists to construct sophisticated molecular architectures efficiently. As a leading global manufacturer, we prioritize safety and compliance in every batch produced, adhering to strict international standards for chemical intermediates.
Technical Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 5-Bromo-2-(Trifluoromethyl)Aniline |
| CAS Number | 703-91-3 |
| Molecular Formula | C7H5BrF3N |
| Molecular Weight | 240.02 g/mol |
| Purity | ≥98.0% |
| Appearance | White to pale yellow crystal powder |
| Boiling Point | 254.8°C at 760 mmHg |
| Density | 1.697 g/cm3 |
| Flash Point | 107.9°C |
| Refractive Index | 1.522 |
Industrial Applications
This fluorinated aniline derivative is extensively utilized in the pharmaceutical industry for the synthesis of kinase inhibitors, receptor modulators, and other small molecule drugs. The electron-withdrawing nature of the trifluoromethyl group modulates the basicity of the amine, influencing binding affinity in biological systems. Key application areas include:
- Development of oncology therapeutics targeting specific cellular pathways.
- Synthesis of agrochemical active ingredients requiring high environmental stability.
- Creation of advanced materials with enhanced thermal and chemical resistance.
- Use as a key intermediate in multi-step organic synthesis routes.
Quality Assurance and Storage
Every production batch undergoes rigorous quality control testing using advanced analytical techniques such as HPLC, GC-MS, and NMR spectroscopy to verify identity and purity. We provide a comprehensive Certificate of Analysis (COA) with every shipment to ensure transparency and compliance with your internal quality standards. Proper storage is essential to maintain product integrity over time.
Store this material in a tightly closed container in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizing agents. Protect from moisture and direct sunlight to prevent degradation. Our packaging options include 25 kg drums with inner plastic bags to ensure safety during global transportation. For specific technical data or custom synthesis requirements, our expert team is available to support your project needs with competitive bulk pricing and reliable supply chain solutions.
