5-Bromo-4-Methylpyridine-2-Carboxylic Acid

Product Overview

5-Bromo-4-Methylpyridine-2-Carboxylic Acid is a specialized heterocyclic building block designed for advanced organic synthesis and medicinal chemistry applications. This compound features a pyridine core substituted with bromine and methyl groups, providing versatile reactivity for cross-coupling reactions and structural diversification. As a key intermediate, it serves as a critical precursor in the development of novel therapeutic agents and functional materials.

Our manufacturing process ensures consistent quality and high purity levels suitable for rigorous research and development environments. The presence of the bromine atom at the 5-position facilitates palladium-catalyzed coupling reactions, while the carboxylic acid moiety allows for further functionalization through amide or ester formation. This dual functionality makes it an invaluable asset for chemists aiming to construct complex molecular architectures efficiently.

Chemical Properties

The physicochemical characteristics of this pyridine derivative support its stability under standard storage conditions while maintaining high reactivity during synthesis. The molecular structure contributes to its solubility profile, which is compatible with various organic solvents commonly used in pharmaceutical processing. The boiling point and density values indicate robust thermal stability, allowing for processing under elevated temperatures when required by specific synthetic routes.

Handling this material requires standard laboratory safety protocols appropriate for fine chemicals. The flash point suggests moderate flammability risks, necessitating storage in cool, ventilated areas away from ignition sources. Proper personal protective equipment should be worn during handling to ensure safety and prevent contamination of the product.

Specifications

Industrial Applications

This compound is primarily utilized as an intermediate in the synthesis of pharmaceutical active ingredients. Its structure is particularly relevant in the design of kinase inhibitors and other targeted therapies where pyridine scaffolds are prevalent. The bromine substituent enables Suzuki, Heck, or Sonogashira coupling reactions, allowing chemists to introduce diverse aryl or alkyl groups to the core structure.

Beyond pharmaceuticals, this chemical finds utility in the development of agrochemicals and specialty materials. The methyl group provides steric and electronic modulation, influencing the biological activity or physical properties of the final product. Researchers value this building block for its reliability in multi-step synthesis pathways, ensuring high yields and minimal byproduct formation.

Quality Assurance and Packaging

We adhere to strict quality control measures to guarantee the integrity of every batch. Each production lot undergoes comprehensive analysis using HPLC and NMR spectroscopy to verify identity and purity. A Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes and test results.

Standard packaging consists of 25 kg drums, ensuring safe transport and storage. Custom packaging solutions are available to meet specific customer requirements. We recommend storing the product in a cool, dry place with adequate ventilation to maintain stability over extended periods. Our global logistics network ensures timely delivery to support your production schedules.