5-Chloro-2-Fluoro-3-Methylpyridine
- CAS No.375368-84-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 5-Chloro-2-Fluoro-3-Methylpyridine (CAS 375368-84-6), a versatile pyridine-based intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
5-Chloro-2-Fluoro-3-Methylpyridine is a high-value heterocyclic building block widely employed in the synthesis of complex active pharmaceutical ingredients (APIs) and specialty agrochemical compounds. This fluorinated and chlorinated pyridine derivative offers exceptional reactivity and selectivity, making it an indispensable intermediate in modern medicinal chemistry workflows.
Specifications
| Molecular Formula | C6H5ClFN |
|---|---|
| Molecular Weight | 145.562 g/mol |
| Density | 1.3 ± 0.1 g/cm³ |
| Boiling Point | 189.4 ± 35.0 °C at 760 mmHg |
| Flash Point | 68.3 ± 25.9 °C |
| Assay | ≥99.0% |
| Appearance | Light Yellow liquid |
| Storage | Store in a cool, ventilated place |
Industrial Applications
As a key structural motif in drug discovery, 5-Chloro-2-Fluoro-3-Methylpyridine serves as a critical precursor in multi-step syntheses requiring regioselective functionalization. Its dual halogen substitution pattern enables sequential cross-coupling reactions—such as Suzuki, Buchwald-Hartwig, or nucleophilic aromatic substitution—facilitating the construction of diverse molecular architectures.
- Ideal for synthesizing kinase inhibitors and other targeted therapeutics
- Used in the development of novel crop protection agents
- Compatible with standard handling protocols for halogenated heterocycles
- Supplied in industrial-scale packaging with full analytical documentation
Our product is manufactured under stringent quality control systems to ensure batch-to-batch consistency, supporting seamless integration into GMP-compliant production pipelines. Custom packaging options are available upon request to meet specific logistical or safety requirements.
