Intermediates

5-Chloro-2-Fluorotoluene

  • CAS No.452-66-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 5-Chloro-2-Fluorotoluene (CAS 452-66-4) designed for pharmaceutical and agrochemical synthesis. Reliable supply with strict quality control and global logistics.

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Product Technical Details

Product Overview

5-Chloro-2-Fluorotoluene represents a critical building block in the realm of modern organic synthesis, particularly valued for its dual halogen substitution pattern. This fluorinated aromatic compound serves as an essential precursor for the development of advanced pharmaceutical agents and high-performance agrochemical formulations. Our manufacturing process ensures exceptional batch-to-batch consistency, meeting the rigorous demands of global research and production facilities.

The strategic placement of chlorine and fluorine atoms on the toluene backbone provides unique reactivity profiles, enabling chemists to perform selective functionalization reactions. This versatility makes it a preferred choice for constructing complex molecular architectures required in medicinal chemistry programs. Fluorine incorporation is known to enhance metabolic stability and bioavailability in drug candidates, making this intermediate highly sought after in the industry.

Key Specifications

ParameterValue
CAS Number452-66-4
Molecular FormulaC7H6ClF
Molecular Weight144.57 g/mol
AppearanceColorless to light yellow transparent liquid
Purity≥98.0%
Density1.188 g/mL at 25 °C
Boiling Point157-159 °C at 752 mm Hg
Refractive Indexn20/D 1.4995
Flash Point120 °F
Water Content≤0.5%

Industrial Applications

As a specialized intermediate, this compound finds extensive utility across multiple high-value sectors. In the pharmaceutical industry, it is utilized for the synthesis of novel therapeutic candidates where fluorine incorporation enhances metabolic stability and bioavailability. The agrochemical sector leverages this material for creating robust crop protection agents that require specific halogenated motifs for efficacy against pests and diseases.

  • Pharmaceutical Intermediate Synthesis
  • Agrochemical Active Ingredient Production
  • Advanced Organic Material Development
  • Custom Chemical Manufacturing Projects
  • Research and Development Laboratories

Quality Assurance and Safety

We adhere to strict quality management systems to guarantee the integrity of every shipment. Each batch undergoes comprehensive analytical testing, including GC-MS and NMR verification, to confirm identity and purity levels. A Certificate of Analysis (COA) is provided with every order to facilitate your internal quality control procedures and regulatory compliance.

Regarding safety, this material is classified as a flammable liquid. Proper storage in a cool, dry, and well-ventilated area is essential. Containers must remain tightly closed when not in use to prevent moisture absorption and vapor release. Our logistics team ensures compliant packaging according to UN transport regulations, guaranteeing safe delivery to your facility.

Partner with us for reliable supply chains and technical expertise in fluorinated chemistry. We are committed to supporting your innovation goals with premium-grade chemical solutions and responsive customer service.