Intermediates

5-Chloro-4-Fluoro-1H-Indole-2-Carboxylic Acid

  • CAS No.186446-26-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 5-Chloro-4-fluoro-1H-indole-2-carboxylic acid (CAS 186446-26-4) for organic synthesis. Available in bulk with COA.

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Product Technical Details

Product Overview

5-Chloro-4-Fluoro-1H-Indole-2-Carboxylic Acid is a specialized heterocyclic compound designed for advanced organic synthesis and pharmaceutical research. As a key building block, this indole derivative offers exceptional reactivity and stability, making it an essential component in the development of complex molecular structures. Our manufacturing process ensures consistent quality and high purity levels to meet the rigorous demands of modern chemical industries.

This compound features a unique substitution pattern with chlorine and fluorine atoms on the indole ring, enhancing its electronic properties for specific coupling reactions. It serves as a critical intermediate in the synthesis of various bioactive molecules, including kinase inhibitors and other therapeutic agents. Researchers and production facilities rely on this material for its reliable performance in multi-step synthesis routes.

Technical Specifications

ParameterValue
Chemical Name5-Chloro-4-Fluoro-1H-Indole-2-Carboxylic Acid
CAS Number186446-26-4
Molecular FormulaC9H5ClFNO2
Molecular Weight213.59 g/mol
AppearanceWhite Powder
Assay≥98.0%
Density1.635 g/cm3
Boiling Point455.4ºC at 760 mmHg
Flash Point229.2ºC

Quality Assurance and Control

We maintain strict quality control protocols throughout the production lifecycle. Every batch undergoes comprehensive testing using advanced analytical techniques such as HPLC, NMR, and Mass Spectrometry. This ensures that the final product meets the specified purity standards and is free from unwanted impurities. A Certificate of Analysis (COA) is provided with every shipment to verify compliance with international quality standards.

Our facility adheres to good manufacturing practices to guarantee product consistency. We understand that trace impurities can significantly impact downstream reactions, which is why our purification processes are optimized to deliver industrial purity suitable for sensitive pharmaceutical applications. Continuous monitoring allows us to maintain tight specifications across large-scale production runs.

Applications and Usage

This indole carboxylic acid derivative is primarily utilized as an intermediate in organic synthesis. It is widely employed in the pharmaceutical industry for constructing complex heterocyclic frameworks. The presence of halogen substituents facilitates various cross-coupling reactions, enabling chemists to introduce diverse functional groups efficiently. It is also valuable in academic research for exploring new chemical spaces and developing novel catalytic systems.

Beyond pharmaceuticals, this compound finds applications in agrochemical research and material science where specific electronic properties are required. Its stability under standard storage conditions makes it a reliable choice for long-term projects. Researchers appreciate its solubility profile and reactivity, which streamline workflow in laboratory settings.

Packaging and Storage

To preserve integrity during transit, the product is packaged in secure 25 kg drums. Custom packaging solutions are available upon request to accommodate specific logistical requirements. Proper sealing ensures protection against moisture and contamination. We recommend storing the material in a cool, ventilated area away from direct sunlight and incompatible substances. Following these guidelines ensures the product remains stable and ready for use upon arrival.

Our global logistics network supports timely delivery to laboratories and manufacturing plants worldwide. We offer competitive bulk pricing for large-volume orders and provide dedicated support for custom synthesis needs. Contact our technical team for detailed information regarding availability, lead times, and specific application guidance.