5-(Chloromethyl)-1,2-dihydro-1,2,4-triazol-3-one
- CAS No.252742-72-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 5-(Chloromethyl)-1,2,4-triazol-3-one (CAS 252742-72-6) designed for pharmaceutical synthesis. Ideal intermediate for antiemetic drug production with strict quality control.
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Product Overview
5-(Chloromethyl)-1,2-dihydro-1,2,4-triazol-3-one is a specialized heterocyclic compound serving as a critical building block in modern pharmaceutical manufacturing. This triazolone derivative is characterized by its high reactivity and stability, making it an essential precursor in the synthesis of complex active pharmaceutical ingredients. Our facility produces this chemical under stringent quality management systems to ensure consistency and reliability for downstream processing.
The compound features a chloromethyl group attached to the triazolone ring, which facilitates nucleophilic substitution reactions required for constructing larger molecular frameworks. It is primarily utilized in the development of antiemetic therapies, specifically contributing to the production of NK1 receptor antagonists. Manufacturers rely on this intermediate for its precise stoichiometry and minimal impurity profile.
Technical Specifications
We adhere to rigorous analytical standards to guarantee the performance of this chemical in industrial applications. Each batch undergoes comprehensive testing using high-performance liquid chromatography and spectral analysis. The following table outlines the key physical and chemical properties associated with this product.
| Parameter | Value |
|---|---|
| CAS Number | 252742-72-6 |
| Molecular Formula | C3H4ClN3O |
| Molecular Weight | 133.536 g/mol |
| Appearance | White to off-white crystalline powder |
| Assay | ≥98.0% |
| Density | 1.8±0.1 g/cm3 |
| Loss on Drying | ≤0.5% |
| Single Impurity | ≤0.5% |
| Ignition Residue | ≤0.2% |
Industrial Applications
This intermediate plays a pivotal role in the pharmaceutical sector, particularly in the synthesis of Aprepitant and Fosaprepitant. These final drugs are widely recognized for their efficacy in preventing nausea and vomiting associated with chemotherapy and surgical procedures. The high purity of our 5-(Chloromethyl)-1,2,4-triazol-3-one ensures that the subsequent coupling reactions proceed with optimal yield and minimal side products.
Beyond antiemetic drugs, this triazolone scaffold is explored in various medicinal chemistry programs targeting neurological and inflammatory pathways. Research and development teams value this material for its versatility in organic synthesis routes. Our production process is optimized to support both pilot-scale experiments and large-scale commercial manufacturing needs.
Quality Assurance and Storage
Maintaining the integrity of this chemical during storage and transport is vital for preserving its reactivity. We recommend storing the material in a cool, dry, and well-ventilated area away from direct sunlight and moisture. Containers should remain tightly sealed when not in use to prevent hydrolysis or contamination. Our packaging options include 25kg drums, with custom configurations available to meet specific logistical requirements.
Every shipment is accompanied by a Certificate of Analysis (COA) detailing the batch-specific test results. Our commitment to quality extends to compliance with international safety standards and environmental regulations. Clients can expect consistent supply chain performance and technical support from our experienced chemistry team.
