5-Cyanoindole
- CAS No.15861-24-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 5-Cyanoindole (CAS 15861-24-2), a key pharmaceutical intermediate used in the synthesis of active pharmaceutical ingredients such as Vilazodone.
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Product Overview
5-Cyanoindole is a high-value heterocyclic organic compound widely employed as a critical building block in modern pharmaceutical synthesis. With the molecular formula C9H6N2 and a molecular weight of 142.16 g/mol, this indole derivative features a nitrile group at the 5-position, imparting enhanced reactivity for downstream functionalization. It serves as an essential intermediate in the production of selective serotonin modulators, including the antidepressant Vilazodone (CAS 163521-12-8).
Specifications
| Molecular Formula | C9H6N2 |
|---|---|
| Molecular Weight | 142.157 g/mol |
| Melting Point | 106–109 °C |
| Density | 1.2 ± 0.1 g/cm³ |
| Boiling Point | 350.0 ± 15.0 °C at 760 mmHg |
| Flash Point | 121.9 ± 5.6 °C |
| Vapour Pressure | 0.0 ± 0.8 mmHg at 25 °C |
| Refractive Index | 1.675 |
Quality Profile
Our 5-Cyanoindole meets stringent quality standards for use in regulated pharmaceutical manufacturing environments. Each batch undergoes rigorous analytical testing to ensure consistency and compliance.
- Appearance: Off-white to yellowish powder
- Assay (HPLC): ≥99.0% (typical result: 99.29%)
- Loss on drying: ≤0.5% (typical: 0.18%)
- Residue on ignition: ≤0.5% (typical: 0.15%)
Industrial Applications
As a versatile synthetic intermediate, 5-Cyanoindole is primarily utilized in the development and large-scale production of central nervous system (CNS) therapeutics. Its robust chemical scaffold enables efficient construction of complex indole-based APIs through nucleophilic addition, cyclization, or cross-coupling reactions. Beyond antidepressants, it also finds application in research programs targeting neuropharmacological agents and kinase inhibitors.
Stored in a cool, dry, and well-ventilated area, the product is typically packed in 25 kg fiber drums with inner polyethylene liners, though custom packaging is available upon request. As a non-final active ingredient, it is intended exclusively for industrial and research use under appropriate regulatory oversight.
