Intermediates

5-Fluoro-2-Hydroxy-3-Nitropyridine

  • CAS No.136888-20-5
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 5-Fluoro-2-Hydroxy-3-Nitropyridine (CAS 136888-20-5) designed for advanced pharmaceutical synthesis. Reliable supply with ≥99.0% assay for global research and production needs.

Request Bulk Pricing

Product Technical Details

Product Overview

5-Fluoro-2-Hydroxy-3-Nitropyridine is a highly specialized fluorinated heterocyclic compound that serves as a critical building block in modern medicinal chemistry. As a key pharmaceutical intermediate, this substance enables the construction of complex molecular architectures required for novel drug discovery and development. The introduction of a fluorine atom at the fifth position of the pyridine ring significantly enhances metabolic stability and bioavailability in downstream active pharmaceutical ingredients. Our facility specializes in the precise synthesis and purification of this nitropyridine derivative, ensuring consistent quality for large-scale production.

Technical Specifications

We adhere to strict quality control protocols to guarantee that every batch meets or exceeds industry standards. The following table outlines the key physical and chemical properties verified through our analytical laboratories.

Parameter Specification
Chemical Name 5-Fluoro-2-Hydroxy-3-Nitropyridine
CAS Number 136888-20-5
Molecular Formula C5H3FN2O3
Molecular Weight 158.09 g/mol
Appearance White Crystalline Powder
Purity (HPLC) ≥99.0%
Boiling Point 249.1ºC at 760mmHg
Density 1.55 g/cm3
Flash Point 104.5ºC

Industrial Applications

This fluorinated pyridine derivative is primarily utilized in the synthesis of kinase inhibitors, antiviral agents, and other therapeutic compounds where metabolic stability is paramount. The nitro group provides a versatile handle for further chemical transformations, including reduction to amines or substitution reactions. Researchers and process chemists value this intermediate for its reactivity profile and compatibility with various catalytic systems. It is an essential component in the manufacturing process of advanced organic synthesis projects targeting neurological and oncological therapeutics.

Quality Assurance and Advantages

Our commitment to excellence is reflected in our comprehensive quality assurance program. Each production lot undergoes rigorous testing using High-Performance Liquid Chromatography (HPLC), Nuclear Magnetic Resonance (NMR), and Mass Spectrometry (MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring full transparency regarding purity and impurity profiles. Choosing our supply chain offers distinct advantages for your production needs.

  • Consistent high purity levels exceeding 99.0% assay.
  • Scalable manufacturing process to support bulk requirements.
  • Robust packaging solutions to maintain stability during transit.
  • Technical support available for synthesis route optimization.

Storage and Handling

To maintain the integrity of 5-Fluoro-2-Hydroxy-3-Nitropyridine, proper storage conditions are essential. The material should be kept in a tightly closed container to prevent moisture absorption and contamination. Store in a cool, dry, and well-ventilated area away from direct sunlight and incompatible substances. Standard industrial safety precautions apply, including the use of appropriate personal protective equipment during handling. We offer flexible packing options, typically 25kg per drum, to suit various logistical requirements for global distribution.