Intermediates

5-Fluoro-2-methylbenzoic acid

  • CAS No.33184-16-6
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 5-Fluoro-2-methylbenzoic acid (CAS 33184-16-6) designed for advanced organic synthesis. Reliable supply with strict quality control for pharmaceutical and chemical intermediates.

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Product Technical Details

Product Overview

5-Fluoro-2-methylbenzoic acid is a specialized fluorinated aromatic compound serving as a critical building block in modern organic synthesis. This carboxylic acid derivative features a strategic methyl substitution at the ortho position and a fluorine atom at the para position relative to the carboxyl group. Such structural configuration enhances its reactivity profile, making it highly valuable for constructing complex molecular architectures in medicinal chemistry and agrochemical development.

Our manufacturing process ensures consistent quality and high purity levels suitable for sensitive downstream reactions. The presence of the fluorine atom imparts unique metabolic stability and lipophilicity to final products, which is often desired in pharmaceutical drug design. As a key intermediate, this compound supports the synthesis of various biologically active molecules where precise substitution patterns are required.

Technical Specifications

ParameterValue
Chemical Name5-Fluoro-2-methylbenzoic acid
CAS Number33184-16-6
Molecular FormulaC8H7FO2
Molecular Weight154.14 g/mol
AppearanceWhite powder
Purity (HPLC)≥99.0%
Melting Point130-132°C
Boiling Point262.1°C
Density1.258 g/cm3
Moisture Content≤0.5%

Industrial Applications

This fluorinated benzoic acid derivative is primarily utilized as a versatile intermediate in the production of pharmaceuticals and fine chemicals. Its specific substitution pattern allows for selective functionalization during multi-step synthesis routes. Common application areas include:

  • Pharmaceutical Intermediate: Used in the development of non-steroidal anti-inflammatory drugs and kinase inhibitors.
  • Agrochemical Synthesis: Serves as a precursor for herbicides and fungicides requiring fluorinated aromatic cores.
  • Material Science: Employed in the creation of specialized polymers and liquid crystal materials.
  • Research and Development: Essential reagent for academic and industrial laboratories focusing on organic methodology.

Quality Assurance and Storage

We adhere to strict quality management systems to guarantee product consistency. Each batch undergoes rigorous testing via HPLC and other analytical methods to verify purity and identity. A Certificate of Analysis (COA) is provided with every shipment to ensure transparency and compliance with international standards.

For optimal stability, store this product in a cool, ventilated area away from direct sunlight and moisture. Keep containers tightly closed when not in use to prevent contamination. Our standard packaging consists of 25 kg drums, though custom packaging solutions are available to meet specific logistical requirements. Global shipping is supported with appropriate safety documentation including MSDS.