5-Fluoro-2-methylpyridine
- CAS No.31181-53-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 5-Fluoro-2-methylpyridine (CAS 31181-53-0) is a essential fluorinated building block for pharmaceutical synthesis. Available in bulk quantities with strict quality control.
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Product Overview
5-Fluoro-2-methylpyridine represents a vital class of fluorinated heterocyclic compounds extensively utilized in modern organic synthesis and medicinal chemistry. As a key structural motif, this chemical building block enables the introduction of fluorine atoms into complex molecular architectures, enhancing metabolic stability and bioavailability in final drug products. Our facility specializes in the large-scale production of this intermediate, ensuring consistent supply chains for global pharmaceutical and agrochemical manufacturers.
The strategic placement of the fluorine atom at the fifth position of the pyridine ring offers unique reactivity profiles suitable for various cross-coupling reactions and nucleophilic substitutions. This versatility makes it an indispensable precursor for developing advanced therapeutic agents and high-performance materials. We adhere to rigorous manufacturing standards to deliver product quality that meets international specifications.
Technical Specifications
Quality assurance is paramount in our production process. Each batch undergoes comprehensive analytical testing using gas chromatography and other advanced methods to verify purity and physical constants. The following table outlines the standard technical parameters for our commercial grade supply:
| Parameter | Specification |
|---|---|
| CAS Number | 31181-53-0 |
| Molecular Formula | C6H6FN |
| Molecular Weight | 111.12 g/mol |
| Appearance | Colorless liquid |
| Purity | ≥99.0% |
| Density | 1.077 g/cm3 |
| Boiling Point | 114.7°C at 760 mmHg |
| Flash Point | 23.1°C |
| Refractive Index | 1.477 |
Industrial Applications
The primary application of 5-Fluoro-2-methylpyridine lies in the synthesis of pharmaceutical active ingredients. Medicinal chemists utilize this intermediate to construct kinase inhibitors, receptor modulators, and other targeted therapies where fluorine substitution is critical for optimizing pharmacokinetic properties. Beyond human health, this compound serves as a valuable precursor in the agrochemical sector for developing novel pesticides and herbicides with improved environmental profiles.
Additionally, the material science industry leverages fluorinated pyridines for creating specialized polymers and liquid crystals. The stability of the carbon-fluorine bond provides thermal and chemical resistance required in high-performance coatings and electronic materials. Our team works closely with R&D departments to support custom synthesis requirements and scale-up processes from laboratory to industrial production.
Quality Assurance and Storage
We maintain a robust quality management system to ensure every drum meets the stated specifications. A Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific test results. Proper handling is essential due to the chemical nature of this product. It should be stored in a tightly closed container within a cool, dry, and well-ventilated area away from incompatible substances.
Safety data indicates a flash point of 23.1°C, classifying it as a flammable liquid. Personnel must utilize appropriate personal protective equipment during handling and transfer operations. Our packaging options include standard 25kg drums, with larger bulk quantities available upon request. We offer global logistics support to ensure timely delivery while maintaining compliance with international hazardous material transportation regulations.
