5-Fluoroindole-2-carboxylic acid
- CAS No.399-76-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity 5-Fluoroindole-2-carboxylic acid (CAS 399-76-8) for pharmaceutical synthesis. Reliable supply with COA.
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Product Overview
5-Fluoroindole-2-carboxylic acid represents a highly specialized fluorinated heterocyclic compound essential for modern medicinal chemistry and advanced organic synthesis. As a key building block, this molecule incorporates a fluorine atom at the fifth position of the indole ring, significantly enhancing its metabolic stability and binding affinity in downstream pharmaceutical applications. Our manufacturing process ensures exceptional consistency, making it an ideal choice for research and development teams focused on kinase inhibitors, receptor modulators, and other complex therapeutic agents.
We understand the critical nature of supply chain reliability in the pharmaceutical industry. Therefore, we maintain strict quality control protocols throughout production. Each batch undergoes rigorous analytical testing to verify identity, purity, and physical characteristics. This commitment to excellence allows us to serve as a trusted partner for both laboratory-scale experiments and large-scale commercial production needs. The strategic placement of the fluorine substituent offers unique electronic properties that facilitate diverse chemical transformations.
Technical Specifications
The following table outlines the key physical and chemical properties of our premium grade 5-Fluoroindole-2-carboxylic acid. These parameters are critical for process engineers and chemists when designing synthesis routes or formulation strategies. Our data is derived from standardized testing methods to ensure accuracy and reproducibility across different batches.
| Parameter | Value |
|---|---|
| CAS Number | 399-76-8 |
| Molecular Formula | C9H6FNO2 |
| Molecular Weight | 179.148 g/mol |
| Appearance | Yellow Powder |
| Assay (Purity) | ≥98.0% |
| Melting Point | 259 °C (dec.) |
| Boiling Point | 422.2±25.0 °C |
| Density | 1.5±0.1 g/cm3 |
Our quality assurance team verifies these specifications against international standards. The high purity level ensures minimal impurities that could interfere with sensitive catalytic reactions or biological assays. We provide comprehensive documentation including Certificates of Analysis for every shipment to support regulatory compliance.
Industrial Applications
This fluorinated indole derivative serves as a versatile intermediate in the synthesis of various bioactive molecules. The introduction of fluorine often improves the pharmacokinetic profile of drug candidates, making this compound particularly valuable in drug discovery pipelines. Chemists utilize this building block to construct complex molecular architectures with precision.
- Pharmaceutical Intermediate: Used in the construction of complex heterocyclic scaffolds for new drug entities.
- Organic Synthesis: Acts as a nucleophile or electrophile partner in cross-coupling reactions and functional group transformations.
- Chemical Research: Employed in academic and industrial laboratories for method development and structure-activity relationship studies.
- Custom Manufacturing: Available for scale-up projects requiring specific particle size or packaging configurations.
Furthermore, the stability of the carboxylic acid group allows for various derivatization reactions, including amide formation and esterification. This versatility expands the scope of potential applications in agrochemicals and material sciences as well.
Storage and Packaging
To maintain product integrity, proper storage conditions are essential. We recommend storing 5-Fluoroindole-2-carboxylic acid in a cool, ventilated area away from direct sunlight and moisture. The compound should be kept in tightly sealed containers to prevent degradation or contamination. Handling should follow standard safety protocols for fine chemicals.
Standard packaging consists of 25 kg drums, which are designed for safe international transport. However, we offer flexible packaging solutions to meet specific customer requirements. Whether you need smaller quantities for pilot studies or bulk shipments for production, our logistics team ensures timely and secure delivery globally. Contact our sales department for detailed information on lead times, shipping methods, and regulatory documentation.
