(5-Formylfuran-2-yl)boronic Acid
- CAS No.27329-70-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity (5-formylfuran-2-yl)boronic acid (CAS 27329-70-0), a key pharmaceutical intermediate used in the synthesis of advanced therapeutic agents such as Lapatinib.
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Product Overview
(5-Formylfuran-2-yl)boronic acid is a high-value boronic acid derivative widely employed as a critical building block in modern medicinal chemistry. With a molecular formula of C5H5BO4 and a molecular weight of 139.90 g/mol, this compound features both an aldehyde and a boronic acid functional group on a furan ring, enabling versatile reactivity in cross-coupling reactions—particularly Suzuki-Miyaura transformations. Its structural duality makes it indispensable for constructing complex heterocyclic scaffolds found in oncology and kinase inhibitor drug candidates.
Specifications
| Molecular Formula | C5H5BO4 |
|---|---|
| Molecular Weight | 139.90 g/mol |
| CAS Number | 27329-70-0 |
| Appearance | Off-white to pale yellow to pink crystalline powder |
| Purity | ≥98.0% |
| Melting Point | 136°C |
| Density | 1.36 g/cm³ |
| Boiling Point | 379.3°C |
| Flash Point | 183.2°C |
| Refractive Index | 1.51 |
| HS Code | 2942000000 |
| UN Number | UN2924 |
| Hazard Class | Class 3, Packing Group II |
Industrial Applications
This boronic acid serves primarily as a synthetic intermediate in the production of targeted kinase inhibitors. Notably, it is a documented precursor in the multi-step synthesis of Lapatinib, a dual tyrosine kinase inhibitor used in breast cancer therapy. Its role in forming carbon-carbon bonds under mild catalytic conditions ensures high yield and selectivity in API manufacturing processes. As a non-final active ingredient, it is strictly intended for research and industrial-scale pharmaceutical synthesis under appropriate regulatory compliance.
Key advantages include:
- High functional group compatibility for modular synthesis
- Excellent stability when stored properly
- Consistent batch-to-batch quality suitable for GMP-aligned workflows
Storage should be in a cool, dry, and well-ventilated area, away from oxidizing agents and moisture. Packaging is typically 25 kg per drum, with custom options available upon request. Note: Supply is restricted in jurisdictions where relevant patents are in force.
