5-Iodouridine
- CAS No.1024-99-3
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 5-Iodouridine (CAS 1024-99-3) designed for pharmaceutical research and nucleoside analog synthesis. Available in bulk quantities with comprehensive quality documentation.
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Product Overview
5-Iodouridine is a specialized halogenated pyrimidine nucleoside derivative that serves as a critical building block in modern medicinal chemistry and pharmaceutical research. As a modified uridine analog, this compound features an iodine substitution at the fifth position of the pyrimidine ring, which significantly alters its electronic properties and reactivity profile. This unique structural characteristic makes it an invaluable intermediate for the synthesis of various antiviral and anticancer agents, as well as for use in oligonucleotide therapeutic development.
Our manufacturing process ensures that every batch of 5-Iodouridine meets stringent quality standards suitable for large-scale industrial applications. The compound is produced under controlled conditions to minimize impurities and ensure consistent performance in downstream synthetic reactions. Researchers and procurement managers rely on this material for its reliability in cross-coupling reactions and nucleophilic substitutions.
Technical Specifications
We maintain rigorous quality control protocols to guarantee the chemical integrity of our products. The following table outlines the key physical and chemical parameters associated with this batch of 5-Iodouridine. All specifications are verified through advanced analytical methods including HPLC and NMR spectroscopy.
| Parameter | Specification |
|---|---|
| Chemical Name | 5-Iodouridine |
| CAS Registry Number | 1024-99-3 |
| Molecular Formula | C9H11IN2O6 |
| Molecular Weight | 370.10 g/mol |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥98.0% |
| Melting Point | 205-207°C |
| Density | 2.27 g/cm3 |
| Refractive Index | 1.748 |
Industrial Applications
The primary utility of 5-Iodouridine lies in its role as a versatile intermediate within the pharmaceutical sector. It is extensively utilized in the development of nucleoside analogs, which are foundational components in the treatment of viral infections and oncological disorders. The iodine atom provides a reactive handle for palladium-catalyzed cross-coupling reactions, enabling chemists to introduce diverse functional groups onto the nucleobase scaffold.
- Antiviral Drug Synthesis: Used as a precursor in creating novel therapies targeting RNA viruses.
- Anticancer Research: Facilitates the development of cytotoxic agents that interfere with DNA replication.
- Oligonucleotide Modification: Essential for labeling and functionalizing RNA and DNA strands for diagnostic purposes.
- Chemical Biology Probes: Employed in studying enzyme mechanisms and cellular uptake pathways.
Quality Assurance and Handling
Quality is paramount in the production of fine chemical intermediates. Each drum of 5-Iodouridine is accompanied by a comprehensive Certificate of Analysis (COA) that details the results of all quality control tests performed. Our facility adheres to Good Manufacturing Practices (GMP) to ensure product safety and consistency. For optimal stability, the material should be stored in a cool, ventilated environment away from direct sunlight and moisture. We offer flexible packaging options, including standard 25 kg drums, and can accommodate custom requirements based on specific logistical needs or production scales.
