5-(Trifluoromethyl)indole
- CAS No.100846-24-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 5-(Trifluoromethyl)indole designed for advanced organic synthesis and medicinal chemistry research applications.
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Product Overview
5-(Trifluoromethyl)indole represents a critical fluorinated building block within the realm of modern medicinal chemistry and organic synthesis. As a specialized intermediate, this compound features a trifluoromethyl group substituted at the fifth position of the indole ring, significantly enhancing its metabolic stability and lipophilicity compared to non-fluorinated analogs. Our facility produces this material under strict quality control protocols to ensure consistency for research and development purposes.
The incorporation of fluorine atoms into organic molecules is a strategic approach in pharmaceutical design, often leading to improved bioavailability and binding affinity. This product serves as a versatile precursor for the development of novel bioactive molecules, kinase inhibitors, and other therapeutic agents. We cater to laboratories and industrial partners requiring reliable sources of high-performance chemical intermediates.
Key Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 100846-24-0 |
| Molecular Formula | C9H6F3N |
| Molecular Weight | 185.146 g/mol |
| Appearance | Off-white to yellow crystalline powder |
| Assay (Purity) | ≥98.0% |
| Melting Point | 67-69°C |
| Boiling Point | 256.7±35.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
Industrial Applications
This fluorinated indole derivative is primarily utilized as a key intermediate in the multi-step synthesis of complex pharmaceutical compounds. Its unique electronic properties make it suitable for various coupling reactions, including Suzuki, Heck, and Buchwald-Hartwig aminations. Researchers value this building block for its ability to introduce specific steric and electronic effects into target molecules.
- Medicinal chemistry research and drug discovery programs.
- Synthesis of heterocyclic compounds and agrochemicals.
- Development of materials science applications requiring stable aromatic systems.
- Custom synthesis projects requiring high-purity fluorinated scaffolds.
Quality Assurance and Packaging
We understand that reproducibility is paramount in chemical research. Every batch of 5-(Trifluoromethyl)indole undergoes rigorous analytical testing, including HPLC and NMR spectroscopy, to verify identity and purity. A Certificate of Analysis (COA) is provided with every shipment to document compliance with specified standards. Our commitment to quality ensures that downstream synthesis processes proceed without interruption due to impurity-related issues.
Standard packaging consists of 25 kg drums, designed to maintain product integrity during transit. However, we offer flexible packaging solutions tailored to specific customer requirements, including smaller quantities for laboratory-scale work. All containers are sealed to prevent moisture absorption and contamination, preserving the chemical stability of the material.
Storage and Handling
To maintain optimal quality, this product should be stored in a cool, ventilated area away from direct sunlight and heat sources. The container must remain tightly closed when not in use to prevent exposure to atmospheric moisture. Proper personal protective equipment (PPE), including gloves and safety goggles, should be worn during handling to ensure safety in accordance with standard laboratory protocols. For detailed safety information, please refer to the Material Safety Data Sheet (MSDS) provided upon request.
