Intermediates

6-Bromo-1H-indole-2-carboxylic acid

  • CAS No.16732-65-3
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 6-Bromo-1H-indole-2-carboxylic acid designed for advanced organic synthesis applications. Available in bulk quantities with comprehensive quality documentation.

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Product Technical Details

Product Overview

6-Bromo-1H-indole-2-carboxylic acid stands as a critical building block within the realm of advanced organic synthesis and pharmaceutical development. This specialized indole derivative features a strategic bromine substitution at the sixth position, rendering it highly valuable for cross-coupling reactions and structural diversification. Our manufacturing process ensures consistent quality and high purity levels, meeting the rigorous demands of modern chemical research and industrial production scales.

As a key intermediate, this compound facilitates the construction of complex molecular architectures found in various therapeutic agents and agrochemical formulations. The carboxylic acid functionality provides additional handles for amidation or esterification, expanding its utility in multi-step synthesis routes. We prioritize safety and compliance throughout our supply chain, ensuring that every batch delivered meets international standards for chemical intermediates.

Key Specifications

ParameterValue
Chemical Name6-Bromo-1H-indole-2-carboxylic acid
CAS Number16732-65-3
Molecular FormulaC9H6BrNO2
Molecular Weight240.053 g/mol
AppearanceOff-white powder
Assay (Purity)≥98.0%
Melting Point221-223°C
Density1.8±0.1 g/cm3
Boiling Point470.9±25.0 °C at 760 mmHg

Industrial Applications

This indole-based intermediate is extensively utilized in the synthesis of kinase inhibitors and other biologically active molecules. The bromine atom serves as an excellent leaving group for palladium-catalyzed coupling reactions, such as Suzuki, Heck, or Sonogashira couplings. Researchers and process chemists rely on this material for developing new drug candidates where the indole scaffold is essential for binding affinity and selectivity.

  • Pharmaceutical API synthesis and process development
  • Agrochemical ingredient manufacturing
  • Material science and functional polymer research
  • Custom organic synthesis projects requiring high purity

Quality Assurance and Logistics

Every production batch undergoes strict quality control testing using advanced analytical techniques including HPLC and NMR spectroscopy. We provide a comprehensive Certificate of Analysis (COA) with each shipment to verify identity and purity. Our packaging options include 25 kg drums or customized solutions based on specific client requirements, ensuring product integrity during transit.

Storage recommendations include keeping the material in a cool, ventilated place away from incompatible substances. Proper handling procedures should be followed to maintain stability and safety. As a global manufacturer, we offer competitive bulk pricing and reliable supply chain solutions to support your long-term production needs. Contact our technical team for detailed specifications or custom synthesis inquiries.