6-Bromonicotinic Acid
- CAS No.6311-35-9
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 6-Bromonicotinic acid (CAS 6311-35-9), a key pyridine-based building block for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
6-Bromonicotinic acid is a high-value halogenated heteroaromatic carboxylic acid widely employed as a versatile intermediate in modern organic synthesis. With its bromine atom positioned at the 6-position of the nicotinic acid scaffold, this compound offers excellent reactivity for transition-metal-catalyzed cross-coupling reactions, including Suzuki, Stille, and Negishi protocols. Its structural features make it particularly valuable in the construction of complex bioactive molecules, functional materials, and specialty ligands.
Specifications
| Molecular Formula | C6H4BrNO2 |
|---|---|
| Molecular Weight | 202.005 g/mol |
| CAS Number | 6311-35-9 |
| Appearance | White to off-white powder |
| Assay | ≥98.0% |
| Melting Point | 200–203 °C (lit.) |
| Density | 1.8 ± 0.1 g/cm³ |
| Boiling Point | 343.3 ± 27.0 °C at 760 mmHg |
| Flash Point | 161.4 ± 23.7 °C |
Industrial Applications
As a specialized pyridine derivative, 6-Bromonicotinic acid serves primarily as a critical synthon in the development of active pharmaceutical ingredients (APIs) and crop protection agents. Its dual functionality—combining an electron-deficient aromatic ring with both carboxylic acid and bromo substituents—enables sequential functionalization strategies in multi-step syntheses. Key application areas include:
- Pharmaceutical intermediates for kinase inhibitors and CNS-targeted therapeutics
- Agrochemical research for novel herbicide and fungicide scaffolds
- Ligand design in catalysis and coordination chemistry
- Building block for functional polymers and electronic materials
Stored in a cool, dry, and well-ventilated environment, this compound maintains stability under standard laboratory conditions. Supplied in 25 kg drums or customized packaging upon request, it meets stringent quality control standards for industrial-scale use.
