Intermediates

6-Chloro-2-methyl-3-nitropyridine

  • CAS No.22280-60-0
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 6-Chloro-2-methyl-3-nitropyridine (CAS 22280-60-0) designed for advanced organic synthesis. Reliable supply with strict quality control for pharmaceutical and agrochemical intermediates.

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Product Technical Details

Product Overview

6-Chloro-2-methyl-3-nitropyridine is a specialized heterocyclic compound widely recognized for its utility in complex organic synthesis pathways. As a substituted pyridine derivative, this chemical features a unique arrangement of chloro, methyl, and nitro functional groups on the pyridine ring, making it a versatile building block for medicinal chemistry and agrochemical development. Our manufacturing process ensures consistent molecular integrity and high purity levels suitable for demanding research and industrial applications.

We understand the critical nature of supply chain reliability in the pharmaceutical and fine chemical sectors. Therefore, every batch of 6-Chloro-2-methyl-3-nitropyridine undergoes rigorous analytical testing to confirm compliance with international standards. This product serves as a key precursor in the synthesis of various bioactive molecules, offering excellent reactivity for nucleophilic substitution and reduction reactions.

Key Specifications

ParameterSpecification
Product Name6-Chloro-2-methyl-3-nitropyridine
CAS Number22280-60-0
Molecular FormulaC6H5ClN2O2
Molecular Weight172.57 g/mol
AppearanceYellow or off-white crystal
Assay (Purity)≥98.0%
Moisture Content≤0.5%
Packaging25 kg/drum or customized

Physical and Chemical Properties

Understanding the physicochemical profile of this intermediate is essential for safe handling and effective process integration. The compound exhibits stable thermal properties within standard storage conditions, with a defined melting point range that aids in identity verification. The density and refractive index values are consistent with high-grade pyridine derivatives, ensuring compatibility with various solvent systems used in downstream processing.

PropertyValue
Density1.406 g/cm3
Melting Point54-58 °C
Boiling Point255.9 °C
Flash Point108.5 °C
Index of Refraction1.575

Industrial Applications

This pyridine derivative is primarily utilized as a strategic intermediate in the manufacture of pharmaceuticals and agricultural chemicals. The presence of the nitro group allows for reduction to an amine, while the chloro substituent provides a site for cross-coupling reactions or nucleophilic displacement. Chemists leverage these reactive sites to construct more complex molecular architectures required for active pharmaceutical ingredients (APIs) and crop protection agents.

  • Pharmaceutical Intermediate: Used in the synthesis of kinase inhibitors and other therapeutic agents.
  • Agrochemical Synthesis: Serves as a precursor for herbicides and fungicides.
  • Material Science: Applicable in the development of specialized polymers and ligands.
  • Research and Development: Essential for medicinal chemistry libraries and structure-activity relationship studies.

Quality Assurance and Storage

Quality is the cornerstone of our production philosophy. We employ advanced chromatographic techniques, including HPLC and GC, to verify the purity and identity of each lot. A Certificate of Analysis (COA) is provided with every shipment, detailing the specific test results for your quality control records. Proper storage is vital to maintain product stability over time.

Store this material in a cool, ventilated place away from direct sunlight and moisture. Ensure containers are tightly sealed when not in use to prevent contamination or degradation. Our packaging options include standard 25 kg drums, with flexibility to accommodate specific customer requirements for bulk shipments or specialized containment. For technical inquiries, safety data sheets, or bulk pricing requests, our expert team is available to support your project needs.