Intermediates

6-Chloro-5-fluoroindole

  • CAS No.122509-72-2
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 6-Chloro-5-fluoroindole (CAS 122509-72-2) designed for advanced organic synthesis. Reliable supply with ≥98.0% assay for pharmaceutical research.

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Product Technical Details

Product Overview

6-Chloro-5-fluoroindole represents a critical halogenated heterocyclic compound extensively utilized within the realm of advanced medicinal chemistry and organic synthesis. As a specialized building block, this indole derivative offers unique reactivity profiles due to the strategic presence of both chlorine and fluorine substituents on the aromatic ring system. Our manufacturing process ensures exceptional batch-to-batch consistency, making it an ideal choice for researchers and industrial chemists seeking reliable raw materials for complex molecule construction. The compound is synthesized under strict quality control protocols to meet international standards for pharmaceutical intermediates, ensuring that every shipment supports your development goals without compromise.

The incorporation of fluorine atoms into organic molecules is a cornerstone strategy in modern drug design, often enhancing metabolic stability and bioavailability. This specific fluorochloroindole variant provides a versatile platform for further functionalization. Whether you are engaged in early-stage discovery or process scale-up, having access to a high-quality source of this intermediate is essential for maintaining project timelines and achieving desired chemical outcomes efficiently.

Technical Specifications

Understanding the precise physicochemical properties of this material is essential for process development and scale-up activities. The following table outlines the key parameters verified through our analytical laboratories. We maintain a high purity standard to minimize impurities that could affect downstream reactions or complicate purification steps. Our quality assurance team utilizes advanced spectroscopic methods to confirm identity and potency.

ParameterSpecification
CAS Number122509-72-2
Molecular FormulaC8H5ClFN
Molecular Weight169.583
AppearanceWhite powder
Assay≥98.0%
Melting Point105-107°C
Boiling Point299.8±20.0 °C at 760 mmHg
Density1.4±0.1 g/cm3
Flash Point135.1±21.8 °C

Industrial Applications

This fluorinated indole serves as a versatile precursor in the synthesis of various bioactive molecules. Its primary utility lies in the construction of kinase inhibitors and other therapeutic agents where halogen substitution plays a pivotal role in binding affinity and metabolic stability. Additionally, it is employed in the development of agrochemicals and functional materials where specific electronic properties are required. The dual halogenation allows for selective functionalization strategies, enabling chemists to introduce diverse structural motifs efficiently through cross-coupling reactions or nucleophilic substitutions.

In the context of pharmaceutical research, this intermediate supports the creation of novel chemical entities targeting various disease pathways. The stability of the indole core combined with the reactivity of the halogen substituents makes it a valuable asset in multi-step synthesis routes. Our clients rely on this material for creating robust synthetic pathways that are scalable and cost-effective, ensuring that final products meet regulatory requirements for purity and safety.

Quality Assurance and Handling

We prioritize product integrity from production to delivery. Each batch is accompanied by a Certificate of Analysis (COA) confirming identity and purity levels based on rigorous testing methods such as HPLC and NMR spectroscopy. Proper storage is crucial to maintain stability over time. The material should be kept in a cool, ventilated environment away from direct sunlight and moisture to prevent degradation. Our packaging options are flexible to accommodate both laboratory-scale research and large-scale industrial production needs, typically supplied in 25 kg drums unless custom requirements are specified.

As a global manufacturer, we understand the importance of supply chain reliability. We maintain adequate stock levels to ensure timely fulfillment of orders worldwide. Our logistics partners are experienced in handling chemical shipments safely and compliantly. By choosing our 6-Chloro-5-fluoroindole, you are partnering with a supplier committed to excellence, safety, and long-term support for your chemical synthesis projects.