Intermediates

6-Chloro-5-fluoroindolin-2-one

  • CAS No.100487-74-9
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity 6-Chloro-5-fluoroindolin-2-one intermediate for advanced organic synthesis. Available in bulk with COA.

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Product Technical Details

Product Overview

6-Chloro-5-fluoroindolin-2-one represents a critical building block in the realm of advanced organic synthesis and medicinal chemistry. This specialized heterocyclic compound features a unique substitution pattern with both chloro and fluoro groups on the indolinone scaffold, offering distinct reactivity profiles for downstream chemical transformations. Our manufacturing facility produces this intermediate under strict quality control protocols to ensure consistent molecular integrity and high purity levels suitable for complex synthesis routes.

As a key precursor in the development of pharmaceutical agents and agrochemical structures, this compound provides excellent stability and solubility characteristics. The presence of halogen substituents allows for versatile cross-coupling reactions and nucleophilic substitutions, making it an invaluable asset for research and development teams focusing on novel molecule discovery. We maintain a robust supply chain to support both laboratory-scale research and large-scale industrial production requirements.

Technical Specifications

ParameterSpecification
Chemical Name6-Chloro-5-fluoroindolin-2-one
CAS Number100487-74-9
Molecular FormulaC8H5ClFNO
Molecular Weight185.583 g/mol
AppearanceLight red crystalline powder
Assay≥98.0%
Melting Point196-206 °C
Density1.5±0.1 g/cm3
Boiling Point327.2±42.0 °C at 760 mmHg
Flash Point151.7±27.9 °C

Industrial Applications

This fluorinated indole derivative serves primarily as a versatile intermediate in the synthesis of complex organic molecules. It is extensively utilized in the pharmaceutical industry for constructing kinase inhibitors and other therapeutic candidates where specific halogen positioning is crucial for biological activity. The compound's structural features enable chemists to introduce specific functional groups at precise locations within a larger molecular framework.

  • Pharmaceutical intermediate for drug discovery programs
  • Building block for agrochemical synthesis
  • Reagent for heterocyclic chemistry research
  • Precursor for material science applications
  • Component in custom synthesis projects

Quality Assurance and Storage

Every batch of 6-Chloro-5-fluoroindolin-2-one undergoes rigorous analytical testing including HPLC, NMR, and mass spectrometry to verify identity and purity. We provide a comprehensive Certificate of Analysis (COA) with each shipment to guarantee compliance with specified standards. Proper storage is essential to maintain product stability over time. The material should be kept in a cool, ventilated environment away from direct sunlight and moisture sources to prevent degradation.

Our packaging options include standard 25 kg drums, with flexibility to accommodate custom requirements based on client logistics needs. We adhere to international safety regulations for the transportation of chemical materials, ensuring secure delivery to global destinations. Our technical support team is available to assist with handling guidelines and synthesis optimization queries.