Intermediates

6-Chloronicotinic Acid

  • CAS No.5326-23-8
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 6-Chloronicotinic Acid (CAS 5326-23-8) designed for pharmaceutical intermediate synthesis, offering excellent stability and reactivity.

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Product Technical Details

Product Overview

6-Chloronicotinic Acid is a highly specialized pyridine derivative that serves as a critical building block in modern organic synthesis. Recognized for its robust chemical structure and versatile reactivity, this compound is extensively utilized in the development of advanced pharmaceutical agents and agrochemical formulations. Our manufacturing process ensures that every batch meets stringent international quality standards, providing reliability for large-scale industrial applications.

As a key intermediate, this acid derivative facilitates complex molecular constructions required in the production of high-value therapeutic compounds. The presence of the chloro substituent on the pyridine ring enhances its utility in nucleophilic substitution reactions, making it a preferred choice for chemists designing sophisticated synthetic routes.

Key Specifications

We maintain rigorous control over physical and chemical parameters to guarantee consistency. The following table outlines the standard specifications and typical analysis results for our premium grade material.

Items of AnalysisStandardTypical Results
AppearanceWhite to slight yellow crystalline powderConform
Purity (HPLC)≥98.0%99.58%
Moisture Content≤0.3%0.11%
Individual Impurity≤1.0%0.14%
Residue on Ignition≤0.5%Conform

Physical and Chemical Properties

Understanding the physicochemical profile is essential for safe handling and process integration. This compound exhibits a molecular formula of C6H4ClNO2 with a molecular weight of approximately 157.55 g/mol. It presents as a stable solid at room temperature with a melting point around 190 degrees Celsius, where decomposition may occur. The boiling point is recorded at 330.1 degrees Celsius under standard atmospheric pressure, indicating high thermal stability suitable for various reaction conditions.

The density is approximately 0.5 g/cm3, and the flash point is measured at 192 degrees Celsius, necessitating standard industrial safety precautions during storage and transport. Its refractive index of 1.590 further confirms the high purity and crystalline nature of the material supplied.

Industrial Applications

The primary application of 6-Chloronicotinic Acid lies in the pharmaceutical sector, where it acts as a precursor for synthesizing advanced dermatological therapeutic agents and other complex organic molecules. It is particularly valued in the production of specific pharmaceutical APIs that require precise halogenated pyridine structures. Beyond pharmaceuticals, this intermediate finds utility in the agrochemical industry for developing novel pesticides and herbicides that demand high stability and efficacy.

Our clients utilize this material for custom synthesis projects, requiring a reliable supply chain that supports both research and development phases as well as full-scale commercial manufacturing. The versatility of this chemical allows for diverse functionalization, enabling the creation of a wide range of downstream products.

Quality Assurance and Safety

Quality is the cornerstone of our operation. Each production batch undergoes comprehensive testing using high-performance liquid chromatography and other analytical methods to verify purity and impurity profiles. We provide a Certificate of Analysis (COA) with every shipment, ensuring full transparency and traceability. Our facilities adhere to strict environmental and safety regulations, minimizing risk and ensuring product integrity.

Storage and Packaging

To maintain optimal quality, 6-Chloronicotinic Acid should be stored in a cool, dry, and well-closed container. It is crucial to keep the material away from moisture, strong light, and excessive heat to prevent degradation. Standard packaging includes 25kg cardboard drums, though we offer flexible packing solutions according to customer specified requirements. Proper handling procedures should be followed in accordance with the provided Material Safety Data Sheet (MSDS) to ensure workplace safety.