6-Chloropyridazin-3-amine
- CAS No.5469-69-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 6-Chloropyridazin-3-amine (CAS 5469-69-2), a key pharmaceutical intermediate used in the synthesis of Montelukast and other bioactive molecules.
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Product Overview
6-Chloropyridazin-3-amine is a high-value heterocyclic building block widely employed in modern pharmaceutical synthesis. With a CAS number of 5469-69-2, this compound serves as a critical intermediate in the production of leukotriene receptor antagonists such as Montelukast. Its well-defined reactivity profile and structural versatility make it indispensable for constructing complex nitrogen-containing scaffolds in active pharmaceutical ingredients (APIs).
Specifications
| Molecular Formula | C₄H₄ClN₃ |
|---|---|
| Molecular Weight | 129.55 g/mol |
| Appearance | Yellow brown powder |
| Purity (HPLC) | ≥99% |
| Moisture Content (KF) | ≤0.02% |
| Melting Point | 210 °C |
| Density | 1.437 ± 0.06 g/cm³ |
| Boiling Point | 363.2 ± 22.0 °C |
Industrial Applications
As a specialized intermediate in medicinal chemistry, 6-Chloropyridazin-3-amine is primarily utilized in the multi-step synthesis of Montelukast (CAS 158965-22-3), a clinically approved drug for asthma and allergic rhinitis. The chlorine atom at the 6-position and the amino group at the 3-position enable selective functionalization through nucleophilic substitution or cross-coupling reactions, facilitating efficient access to target molecules.
- Serves as a core scaffold for pyridazine-based drug candidates
- Enables regioselective derivatization in API synthesis
- Compatible with standard industrial-scale reaction conditions
- Supplied with full analytical documentation including COA and HPLC chromatograms
Handling and Storage
This product should be stored in a cool, dry, and tightly sealed container under inert atmosphere when possible. Protect from moisture, direct sunlight, and excessive heat to maintain stability and purity over time. Standard industrial hygiene practices are recommended during handling.
