6-Fluoro-2-methyl-1H-indole
- CAS No.40311-13-5
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 6-Fluoro-2-methyl-1H-indole (CAS 40311-13-5), a key building block for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
6-Fluoro-2-methyl-1H-indole is a fluorinated heterocyclic compound belonging to the indole family, widely recognized for its utility as a versatile intermediate in complex organic synthesis. With a molecular formula of C9H8FN and a molecular weight of 149.165 g/mol, this compound features a strategically positioned fluorine atom at the 6-position and a methyl group at the 2-position, enhancing its electronic and steric profile for targeted molecular construction. It appears as a brown to purple solid with a melting point of approximately 100°C and demonstrates high chemical stability under standard storage conditions.
Specifications
| Molecular Formula | C9H8FN |
|---|---|
| Molecular Weight | 149.165 g/mol |
| CAS Number | 40311-13-5 |
| Appearance | Brown to purple solid |
| Assay | ≥98.0% |
| Density | 1.2 ± 0.1 g/cm³ |
| Boiling Point | 269.2 ± 20.0 °C at 760 mmHg |
| Flash Point | 116.6 ± 21.8 °C |
| Vapour Pressure | 0.0 ± 0.5 mmHg at 25°C |
| Refractive Index | 1.627 |
Industrial Applications
This compound serves primarily as a high-value intermediate in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. Its fluorinated indole core enables medicinal chemists to fine-tune pharmacokinetic properties such as metabolic stability, membrane permeability, and target binding affinity. Common applications include:
- Synthesis of novel neurological and anti-inflammatory therapeutics
- Construction of fused heterocyclic scaffolds in drug discovery programs
- Development of selective enzyme inhibitors and receptor modulators
- Use in cross-coupling and electrophilic substitution reactions due to its activated aromatic system
Stored in a cool, well-ventilated area away from oxidizing agents, 6-Fluoro-2-methyl-1H-indole maintains integrity over extended periods. Standard packaging is 25 kg per drum, with custom options available to meet specific logistical or regulatory requirements. As a non-controlled, non-hazardous research chemical, it is compliant with international trade regulations for B2B chemical supply.
