6-Iodo-4-quinazolinol
- CAS No.16064-08-7
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 6-Iodo-4-quinazolinol (CAS 16064-08-7) designed for pharmaceutical synthesis. Ideal intermediate for Lapatinib production with ≥98.0% purity.
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Product Overview
6-Iodo-4-quinazolinol is a highly specialized heterocyclic compound serving as a critical building block in modern medicinal chemistry. As a halogenated quinazoline derivative, this molecule features a strategic iodine substitution at the sixth position, enabling versatile cross-coupling reactions essential for constructing complex kinase inhibitor scaffolds. Our manufacturing facility produces this intermediate under strict quality control protocols to ensure consistency for downstream pharmaceutical applications.
This chemical entity is particularly valued in the oncology sector, where quinazoline cores are fundamental to tyrosine kinase inhibitor development. The high reactivity of the iodine moiety allows chemists to efficiently introduce various functional groups, facilitating the synthesis of targeted therapeutics. We supply this material to research institutions and pharmaceutical manufacturers globally, supporting the development of life-saving medications.
Technical Specifications
We adhere to rigorous analytical standards to guarantee the quality of every batch. The following table outlines the key physical and chemical properties verified through our quality assurance laboratory. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) detailing test results against these specifications.
| Parameter | Specification |
|---|---|
| Chemical Name | 6-Iodo-4-quinazolinol |
| CAS Number | 16064-08-7 |
| Molecular Formula | C8H5IN2O |
| Molecular Weight | 272.04 g/mol |
| Purity | ≥98.0% |
| Appearance | Brown powder |
| Melting Point | 272-274°C |
| Density | 2.11 g/cm³ |
| Storage Conditions | Cool, ventilated place |
Industrial Applications
The primary application of 6-Iodo-4-quinazolinol is as a key intermediate in the synthesis of Lapatinib, a dual tyrosine kinase inhibitor used in the treatment of breast cancer. The structural integrity of this intermediate directly impacts the efficacy and safety profile of the final active pharmaceutical ingredient (API). Beyond Lapatinib, this compound serves as a versatile precursor for various quinazoline-based drug candidates targeting epidermal growth factor receptors (EGFR).
Our clients utilize this material in multi-step organic synthesis routes requiring high regioselectivity. The robust quality of our product minimizes purification burdens during subsequent reaction steps, thereby improving overall process efficiency and yield. We support scale-up production from laboratory grams to commercial kilogram quantities, ensuring seamless transition from research to manufacturing.
Quality Assurance and Safety
Safety and compliance are paramount in our operations. This product is classified under Hazard Class 8, and we ensure all packaging meets international transportation regulations, including UN1759 standards. Our facilities operate under GMP-inspired guidelines to maintain product integrity throughout the manufacturing process. We recommend storing the material in a cool, ventilated environment away from incompatible substances to preserve stability.
We provide full technical support for our customers, including assistance with synthesis route optimization and regulatory documentation. Our commitment to transparency means every batch is traceable, and we maintain strict confidentiality regarding client projects. For bulk orders, custom packaging solutions are available to meet specific logistical requirements. Contact our sales team for current availability, pricing, and detailed safety data sheets.
