Intermediates

6-Methoxy-2-(4-methoxyphenyl)benzo[b]thiophene

  • CAS No.63675-74-1
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity 6-Methoxy-2-(4-methoxyphenyl)benzo[b]thiophene (CAS 63675-74-1) supplied for Raloxifene synthesis. Reliable global manufacturer with COA.

Request Bulk Pricing

Product Technical Details

Product Overview

6-Methoxy-2-(4-methoxyphenyl)benzo[b]thiophene is a highly specialized pharmaceutical intermediate characterized by its distinct benzo[b]thiophene core structure. This compound serves as a critical building block in the multi-step synthesis of Raloxifene hydrochloride, a well-known selective estrogen receptor modulator (SERM). Our manufacturing process ensures exceptional chemical stability and consistency, making it an ideal choice for large-scale pharmaceutical production.

As a key precursor, this molecule features dual methoxy substitutions that enhance its reactivity profile during subsequent coupling reactions. The structural integrity of the thiophene ring is maintained through rigorous purification protocols, ensuring minimal impurity levels that could affect downstream synthesis efficiency.

Technical Specifications

ParameterValue
CAS Number63675-74-1
Molecular FormulaC16H14O2S
Molecular Weight270.346 g/mol
AppearanceWhite to off-white powder
Assay (Purity)≥98.0%
Melting Point191-197 °C
Boiling Point435.7±35.0 °C at 760 mmHg
Density1.2±0.1 g/cm3
Flash Point217.3±25.9 °C

Industrial Applications

The primary application of this intermediate lies in the pharmaceutical sector, specifically within the production pipeline for osteoporosis and breast cancer prevention therapies. It acts as a foundational scaffold that enables the construction of the complex pharmacophore required for biological activity. Chemical manufacturers utilize this substance to streamline the synthesis route, reducing overall production time and cost while maintaining high yield standards.

Beyond its direct use in Raloxifene synthesis, this benzo[b]thiophene derivative is also explored in medicinal chemistry research for developing novel analogs with improved therapeutic indices. Its robust chemical properties allow for various functional group transformations, providing flexibility for process chemists designing new drug candidates.

Quality Assurance and Packaging

We adhere to strict quality management systems to guarantee product consistency. Each batch undergoes comprehensive analysis using HPLC and NMR spectroscopy to verify structural identity and purity levels. A Certificate of Analysis (COA) is provided with every shipment, detailing all relevant test results against established specifications.

Standard packaging consists of 25 kg drums lined with protective materials to prevent moisture absorption and contamination. Custom packaging solutions are available upon request to meet specific logistical requirements. Proper storage in a cool, ventilated area ensures the material retains its specified properties over extended periods.

Why Choose Our Supply

  • Consistent high purity levels exceeding 98%.
  • Scalable production capacity for bulk orders.
  • Comprehensive technical support and documentation.
  • Reliable global shipping and logistics network.
  • Competitive pricing structures for long-term partnerships.

Partner with us for a secure supply chain of essential pharmaceutical intermediates. Our commitment to quality and compliance makes us a trusted source for global chemical procurement needs.