Intermediates

6-Methyl-5-nitropyridin-2-amine

  • CAS No.22280-62-2
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 6-methyl-5-nitropyridin-2-amine (CAS 22280-62-2), a key pyridine-based intermediate for advanced organic synthesis in pharmaceutical and agrochemical manufacturing.

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Product Technical Details

Product Overview

6-Methyl-5-nitropyridin-2-amine is a high-value heterocyclic building block widely employed as an intermediate in the synthesis of complex organic molecules. With its distinctive nitro and amino functional groups positioned on a methyl-substituted pyridine core, this compound offers versatile reactivity for nucleophilic substitution, reduction, and cross-coupling transformations. It serves as a critical precursor in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals, where structural precision and purity are paramount.

Specifications

Molecular FormulaC6H7N3O2
Molecular Weight153.14 g/mol
CAS Number22280-62-2
AppearanceYellow or green crystalline powder
Purity (HPLC)≥99.0%
Density1.354 g/cm³
Melting Point185–189°C
Boiling Point327.3°C
Flash Point151.7°C

Industrial Applications

This compound is primarily utilized as a specialized intermediate in multi-step synthetic routes within the pharmaceutical and crop protection industries. Its electron-deficient aromatic system facilitates regioselective modifications, enabling the construction of structurally diverse target molecules. Common downstream applications include the preparation of kinase inhibitors, antimicrobial scaffolds, and herbicidal agents. Due to its high chemical stability under standard handling conditions, it integrates seamlessly into large-scale manufacturing processes.

  • Enables efficient access to functionalized pyridine derivatives
  • Compatible with modern catalytic transformation protocols
  • Supplied in industrial-grade purity with full analytical documentation
  • Custom packaging available for seamless integration into production workflows

Storage recommendations include keeping the material in a cool, dry, and well-ventilated area, away from strong oxidizing agents and sources of ignition. Standard packaging is 25 kg per fiber drum, with tailored solutions available upon request.