Intermediates

6-(Trifluoromethyl)indole

  • CAS No.13544-43-9
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity 6-(Trifluoromethyl)indole (CAS 13544-43-9) is a key fluorinated building block for pharmaceutical organic synthesis. Available in bulk with strict quality control.

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Product Technical Details

Product Overview

6-(Trifluoromethyl)indole represents a critical fluorinated heterocyclic building block extensively utilized in modern medicinal chemistry and advanced organic synthesis. The strategic incorporation of the trifluoromethyl group significantly enhances the metabolic stability and lipophilicity of resulting pharmaceutical compounds, making this intermediate highly valuable for diverse drug discovery programs. Our facility produces this compound under strict quality management systems to ensure consistent batch-to-batch reliability for research and commercial applications.

The molecular structure features a robust indole core substituted with a trifluoromethyl group at the sixth position. This specific configuration offers unique reactivity profiles that are essential for constructing complex molecular architectures. Researchers and process chemists value this material for its compatibility with various coupling reactions and its stability under standard laboratory conditions. We are committed to supplying high-grade chemical intermediates that meet the rigorous demands of the global pharmaceutical industry.

Technical Specifications

Quality control is paramount in our manufacturing process. Each batch undergoes rigorous analytical testing to verify physical constants and chemical purity. The product is supplied as an off-white to yellow powder with an assay purity exceeding 98.0 percent. Detailed physical constants including melting point, boiling point, and density are verified through advanced analytical instrumentation to ensure compliance with specified standards.

ParameterValue
CAS Number13544-43-9
Molecular FormulaC9H6F3N
Molecular Weight185.146
AppearanceOff-white to yellow powder
AssayGreater than or equal to 98.0 percent
Melting Point101 degrees Celsius
Boiling Point256.7 plus or minus 35.0 degrees Celsius at 760 mmHg
Density1.4 plus or minus 0.1 g per cm3

Industrial Applications

Primary applications include the synthesis of kinase inhibitors, agrochemical agents, and specialized organic materials. The indole core serves as a versatile scaffold for constructing complex molecular architectures used in therapeutic development. The fluorinated nature of this intermediate allows for improved binding affinity in biological systems, which is a key consideration in modern drug design strategies.

From a logistical standpoint, we maintain robust supply chain capabilities to support global distribution. Whether for pilot scale research or commercial production runs, our team provides technical support to facilitate smooth integration into your synthesis routes. Safety data sheets and regulatory documentation are available upon request to ensure compliance with local import regulations and workplace safety standards.

Quality Assurance and Logistics

The manufacturing process employs advanced catalytic methods to minimize impurities and maximize yield. Our production lines are equipped with state-of-the-art purification technologies ensuring the removal of residual solvents and by-products. This commitment to purity reduces downstream processing costs for our clients and ensures higher success rates in subsequent reaction steps.

We offer flexible packaging options including 25 kg drums or customized solutions based on client logistics requirements. Storage recommendations emphasize cool, ventilated environments to maintain chemical integrity over extended periods. Proper handling procedures should always be followed to ensure personnel safety and environmental protection. Contact our sales team for detailed information on bulk pricing and availability.