6-(Trifluoromethyl)indoline
- CAS No.181513-29-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 6-(Trifluoromethyl)indoline (CAS 181513-29-1) designed for advanced pharmaceutical synthesis. Reliable supply with strict quality control.
Request Bulk PricingProduct Technical Details
Product Overview
6-(Trifluoromethyl)indoline is a specialized fluorinated heterocyclic compound that serves as a vital building block in modern medicinal chemistry and organic synthesis. As a derivative of the indoline scaffold, this molecule incorporates a trifluoromethyl group at the sixth position, significantly enhancing its metabolic stability and lipophilicity compared to non-fluorinated analogs. These physicochemical properties make it an invaluable intermediate for the development of novel pharmaceutical agents, particularly in the fields of oncology and central nervous system therapeutics.
Our manufacturing process ensures that every batch meets rigorous international standards for purity and consistency. We understand the critical role this intermediate plays in multi-step synthesis routes, which is why we prioritize strict quality assurance protocols from raw material sourcing to final packaging. Whether utilized for lead optimization or large-scale production, this compound provides a reliable foundation for complex molecular construction.
Key Specifications
To support reproducible research and manufacturing outcomes, we provide comprehensive physical and chemical data for every lot. The following table outlines the standard specifications for our commercial grade 6-(Trifluoromethyl)indoline:
| Parameter | Specification |
|---|---|
| Chemical Name | 6-(Trifluoromethyl)indoline |
| CAS Registry Number | 181513-29-1 |
| Molecular Formula | C9H8F3N |
| Molecular Weight | 187.162 g/mol |
| Appearance | Yellow crystalline powder |
| Assay (Purity) | ≥98.0% |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 221.4±40.0 °C at 760 mmHg |
| Flash Point | 87.7±27.3 °C |
| Refractive Index | 1.481 |
Industrial Applications
The primary application of 6-(Trifluoromethyl)indoline lies in the synthesis of advanced pharmaceutical intermediates. The indoline core is a privileged structure found in numerous bioactive molecules, and the addition of the trifluoromethyl moiety often improves binding affinity to target proteins. Chemists utilize this building block to construct kinase inhibitors, receptor modulators, and other small molecule drugs. Beyond pharmaceuticals, it may also find utility in agrochemical research and material science where fluorinated heterocycles are required for specific performance characteristics.
Our clients value this product for its compatibility with various synthetic transformations, including nucleophilic substitutions and coupling reactions. The high purity level minimizes side reactions, ensuring higher yields in downstream processes. This efficiency is crucial for reducing overall production costs and accelerating time-to-market for new chemical entities.
Quality Assurance and Packaging
We are committed to delivering products that exceed industry expectations. Each shipment is accompanied by a Certificate of Analysis (COA) detailing the test results for identity, purity, and physical properties. Our facility operates under strict safety and environmental guidelines to ensure sustainable production practices.
For standard orders, the product is packaged in 25 kg drums, which are designed to protect the material from moisture and light during transit. However, we recognize that different projects have varying requirements. Therefore, we offer flexible packaging solutions tailored to customer needs. Storage recommendations include keeping the container in a cool, ventilated place away from incompatible substances to maintain stability over time. Partner with us for a reliable supply chain of high-performance chemical intermediates.
