6-(Trifluoromethyl)pyridin-2(1H)-one

Product Overview

6-(Trifluoromethyl)pyridin-2(1H)-one stands as a pivotal fluorinated heterocyclic building block within the landscape of modern organic synthesis and medicinal chemistry. This compound is distinguished by the strategic placement of a trifluoromethyl group at the sixth position of the pyridine ring, a structural feature that imparts significant electronic and steric influences on subsequent chemical transformations. The introduction of fluorine atoms into pharmaceutical scaffolds is a well-established strategy to enhance metabolic stability, improve membrane permeability, and modulate binding affinity to biological targets. Our organization is dedicated to supplying this critical intermediate with uncompromising quality, supporting research laboratories and manufacturing plants worldwide in their pursuit of novel therapeutic agents.

Chemical Properties

The chemical profile of 6-(Trifluoromethyl)pyridin-2(1H)-one is characterized by its robust stability under standard laboratory conditions. With a molecular weight of 163.097 and a molecular formula of C6H4F3NO, it presents as an off-white powder with high purity levels. The boiling point and density specifications indicate its suitability for various processing techniques including recrystallization and chromatographic purification. The electron-withdrawing nature of the trifluoromethyl substituent activates the ring system for nucleophilic substitutions while maintaining resistance against oxidative degradation. These properties make it an ideal candidate for complex multi-step synthesis routes where functional group tolerance is paramount.

Technical Specifications

Industrial Applications

In the pharmaceutical industry, this pyridone derivative serves as a foundational element for constructing kinase inhibitors, G-protein coupled receptor modulators, and anti-inflammatory agents. The versatility of the hydroxy-pyridine motif allows for diverse derivatization, enabling chemists to explore extensive structure-activity relationships. Beyond human health, the compound finds utility in agrochemical development, where fluorinated structures often confer enhanced environmental stability and biological potency. Our clients leverage this intermediate to accelerate their drug discovery timelines, relying on our consistent supply chain to prevent project delays.

• Medicinal chemistry research and development
• Scale-up production of drug candidates
• Agrochemical formulation synthesis
• Material science applications requiring fluorinated heterocycles

Quality Assurance and Handling

Quality assurance is the cornerstone of our manufacturing philosophy. Every batch of 6-(Trifluoromethyl)pyridin-2(1H)-one undergoes rigorous analytical testing using high-performance liquid chromatography and nuclear magnetic resonance spectroscopy. We maintain strict control over impurity profiles, ensuring that water content remains below specified limits to prevent hydrolysis during storage. Our facilities comply with international safety standards, and each shipment is documented with a comprehensive Certificate of Analysis. We offer flexible packaging solutions, typically 25kg drums, customized to meet specific logistical requirements. Proper storage in a cool, dry, and well-ventilated environment is recommended to preserve product integrity over extended periods. Our technical support team is available to assist with synthesis optimization and regulatory documentation needs.