6,7-Dimethoxyquinazoline-2,4-dione
- CAS No.28888-44-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 6,7-Dimethoxyquinazoline-2,4-dione (CAS 28888-44-0), a key pharmaceutical intermediate for the synthesis of antihypertensive agents such as Alfuzosin and Prazosin hydrochloride.
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Product Overview
6,7-Dimethoxyquinazoline-2,4-dione is a high-value heterocyclic compound widely employed as a critical building block in the pharmaceutical industry. With the CAS number 28888-44-0 and molecular formula C10H10N2O4 (MW: 222.20 g/mol), this compound serves as an essential intermediate in the synthesis of selective alpha-1 adrenergic receptor antagonists, including Alfuzosin hydrochloride and Prazosin hydrochloride—both clinically used for the management of hypertension and benign prostatic hyperplasia.
Specifications
| Molecular Formula | C10H10N2O4 |
|---|---|
| Molecular Weight | 222.20 g/mol |
| Melting Point | 323 °C |
| Density | 1.312 g/cm³ |
| Boiling Point | 507.9 ± 60.0 °C at 760 mmHg |
| Refractive Index | 1.552 |
| Appearance | White to pale yellow crystalline powder |
| Purity (HPLC) | ≥98.0% |
| Water Content | ≤0.3% |
| Residue on Ignition | ≤0.5% |
| Total Impurities | ≤1.0% |
| Single Impurity | ≤0.5% |
Industrial Applications
This quinazoline derivative is exclusively utilized as a synthetic intermediate in regulated pharmaceutical manufacturing processes. Its structural motif enables efficient construction of complex active pharmaceutical ingredients (APIs) targeting cardiovascular and urological conditions. Key advantages include:
- High chemical stability under standard processing conditions
- Excellent reactivity profile for nucleophilic substitution and cyclization steps
- Consistent batch-to-batch quality suitable for GMP-compliant API synthesis
- Compatibility with large-scale industrial manufacturing protocols
Stored in tightly sealed containers in a cool, dry, and well-ventilated environment, the product maintains integrity during extended shelf life. Standard packaging is 25 kg fiber drums, with custom configurations available upon request.
