7-Oxolithocholic Acid
- CAS No.4651-67-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 7-Oxolithocholic Acid (CAS 4651-67-6), a key bile acid intermediate used in the synthesis of Ursodeoxycholic Acid and other advanced pharmaceutical intermediates.
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Product Overview
7-Oxolithocholic Acid is a high-value bile acid derivative widely utilized as a critical intermediate in the pharmaceutical synthesis of hepatoprotective agents, particularly in the production of Ursodeoxycholic Acid (UDCA). With a well-defined steroidal backbone featuring a 3α-hydroxy group and a 7-keto functionality, this compound serves as a strategic building block in complex organic synthesis pathways targeting metabolic and gastrointestinal therapeutics.
Specifications
| Molecular Formula | C24H38O4 |
|---|---|
| Molecular Weight | 390.56 g/mol |
| CAS Number | 4651-67-6 |
| Appearance | White powder |
| Purity | ≥99.0% |
| Any Other Impurity | ≤1.0% |
| Heavy Metals | ≤20 ppm |
| Residue on Ignition | ≤5.0% |
| Melting Point | 205°C |
| Density | 1.124 g/cm³ |
| Boiling Point | 545.9°C at 760 mmHg |
| Refractive Index | 1.535 |
Industrial Applications
As a specialized intermediate in bile acid chemistry, 7-Oxolithocholic Acid plays an essential role in multi-step syntheses within the pharmaceutical industry. Its primary application lies in the controlled reduction to produce Ursodeoxycholic Acid (CAS 128-13-2), a clinically approved drug for dissolving cholesterol gallstones and treating primary biliary cholangitis. Additionally, it may serve as a reference standard or precursor in research related to nuclear receptor modulation, including TGR5 (G protein-coupled bile acid receptor) studies, supporting the development of novel metabolic disorder therapeutics.
- High chemical stability under standard storage conditions
- Consistent batch-to-batch quality suitable for GMP-compliant processes
- Compatible with standard hydrogenation and functional group transformation protocols
Storage and Packaging
Store in a tightly closed container in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizers or acids. Supplied in 25 kg fiberboard drums with inner polyethylene liners, or customized packaging per client requirements. Certificates of Analysis (COA) are provided with every batch to ensure traceability and compliance with international regulatory standards.
