Azetidine
- CAS No.503-29-7
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Azetidine liquid intermediate for pharmaceutical synthesis. Reliable supply with strict quality control and global shipping capabilities.
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Product Overview
Azetidine, identified by CAS number 503-29-7, is a fundamental heterocyclic amine characterized by a four-membered saturated ring containing one nitrogen atom. As a strained cyclic amine, it possesses unique reactivity profiles that make it indispensable in modern medicinal chemistry and organic synthesis. Our facility produces high-grade Azetidine designed specifically for use as a versatile building block in the development of complex pharmaceutical agents and advanced organic materials.
This compound serves as a critical scaffold in drug discovery, often utilized to mimic proline residues or to introduce conformational constraints into peptide mimetics. The inherent ring strain of the azetidine moiety enhances its nucleophilicity compared to acyclic amines, facilitating various substitution and ring-opening reactions. We adhere to stringent manufacturing protocols to ensure consistent quality, purity, and performance for our global clientele.
Key Specifications
| Parameter | Specification |
|---|---|
| Appearance | Clear colorless liquid |
| Purity | ≥98.0% |
| Water Content | 0.5% Max. |
| Sulfated Ash | 0.1% Max. |
| Heavy Metals | 10ppm Max |
| Total Impurity | 0.2% Max. |
| Microbial Limits | Total plate count ≤1000cfu/g |
Physical Properties
Understanding the physical characteristics of Azetidine is essential for safe handling and process optimization. The material presents as a clear, colorless liquid with a distinct amine odor. Its physical constants are well-documented to assist chemists in designing reaction conditions and purification strategies.
| Property | Value |
|---|---|
| Molecular Formula | C3H7N |
| Molecular Weight | 57.09 g/mol |
| Density | 0.847 g/mL at 25 °C |
| Boiling Point | 61-62 °C |
| Flash Point | -5 °F |
| Refractive Index | n20/D 1.432 |
Industrial Applications
The versatility of Azetidine extends across multiple sectors within the chemical and pharmaceutical industries. Its primary utility lies in the construction of nitrogen-containing heterocycles which are prevalent in bioactive molecules.
- Pharmaceutical Intermediates: Used extensively in the synthesis of antibiotics, antivirals, and kinase inhibitors.
- Medicinal Chemistry: Employed as a proline surrogate to improve metabolic stability and bioavailability of peptide drugs.
- Organic Synthesis: Acts as a nucleophile in alkylation and acylation reactions for creating complex molecular architectures.
- Agrochemical Development: Utilized in the formulation of novel pesticides and herbicides requiring specific nitrogenous scaffolds.
Storage and Handling
Proper storage is vital to maintain the integrity and safety of Azetidine. The product should be kept in a tightly closed container to prevent moisture absorption and oxidation. Facilities must ensure storage areas are cool, dry, and well-ventilated, away from incompatible substances such as strong oxidizing agents and acids. Due to its flammability and potential health hazards, appropriate personal protective equipment (PPE) including gloves and eye protection must be worn during handling. We recommend consulting the Safety Data Sheet (SDS) for comprehensive hazard information and emergency procedures.
Our packaging options include 25 kg drums, with customization available to meet specific logistical requirements. As a committed global manufacturer, we provide full documentation including Certificates of Analysis (COA) with every shipment to guarantee compliance with international quality standards.
