Azidotrimethylsilane
- CAS No.4648-54-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Azidotrimethylsilane (CAS 4648-54-8) designed for advanced organic synthesis and azide transfer reactions. Reliable supply with comprehensive COA.
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Product Overview
Azidotrimethylsilane, frequently recognized in chemical literature as Trimethylsilyl azide, stands as a pivotal reagent within the realm of advanced organic synthesis. This specialized organosilicon compound serves as a safer and more manageable alternative to hydrazoic acid for introducing azide functionalities into complex molecular structures. Our manufacturing process ensures exceptional purity levels, making it an ideal choice for pharmaceutical intermediates, fine chemical production, and materials science research. The compound is characterized by its stability under normal storage conditions and its high reactivity in specific catalytic environments, providing chemists with a reliable tool for constructing nitrogen-containing heterocycles.
Technical Specifications
| Parameter | Specification |
|---|---|
| Appearance | Colorless to pale yellow liquid |
| Assay (Purity) | ≥95.0% (Typical 97.47%) |
| Hydroxytrimethylsilane | ≤5.0% |
| TMSCI Impurity | ≤0.5% |
| Moisture Content | ≤0.5% |
| DCM Residual | ≤3.0% |
| Boiling Point | 92-95 °C |
| Density | 0.876 g/mL at 20 °C |
Industrial Applications
The versatility of Azidotrimethylsilane extends across multiple sectors of the chemical industry. Primarily, it is utilized as a critical intermediate in the synthesis of pharmaceutical APIs where azide groups are required precursors for amines or triazoles. In materials science, it facilitates surface modification processes through click chemistry reactions. The reagent is particularly valued for its ability to participate in Staudinger reductions and cycloaddition reactions without the extreme hazards associated with inorganic azides. Our clients leverage this product for developing novel polymers, agrochemicals, and specialized catalysts where precise nitrogen incorporation is essential for performance.
- Efficient azide transfer agent for organic transformations
- Key component in click chemistry and bioconjugation
- Safer alternative to hydrazoic acid in laboratory settings
- Precursor for synthesizing tetrazoles and triazoles
- Compatible with various transition metal catalysts
Quality Assurance and Manufacturing
As a dedicated global manufacturer, we implement rigorous quality control protocols at every stage of production. Each batch of Azidotrimethylsilane undergoes comprehensive analysis using gas chromatography and Karl Fischer titration to verify purity and moisture content. We provide a complete Certificate of Analysis (COA) with every shipment, ensuring transparency and compliance with international chemical standards. Our facility operates under strict environmental and safety guidelines, guaranteeing that the product meets the high expectations of B2B partners in the pharmaceutical and fine chemical sectors. Consistency in batch-to-bquality is our priority, supporting your large-scale manufacturing needs.
Storage and Handling
Proper storage is crucial to maintain the integrity of this chemical reagent. Azidotrimethylsilane should be kept in tightly closed containers within a refrigerated environment to prevent decomposition and moisture absorption. The compound is sensitive to water, which can lead to hydrolysis, so handling should occur under inert atmosphere conditions when possible. Safety data sheets indicate that while stable at room temperature in closed containers, appropriate personal protective equipment must be worn during handling. We recommend consulting our technical team for specific guidance on integration into your synthesis routes to ensure optimal safety and reaction yields.
