Boc-D-Dap-OH

Product Overview

Boc-D-Dap-OH, chemically designated as (2R)-3-amino-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid, is a protected D-configured diaminopropionic acid derivative. This compound features a tert-butoxycarbonyl (Boc) protecting group on the alpha-amino functionality, rendering it highly valuable in stereoselective organic synthesis and solid-phase peptide assembly. With a molecular formula of C8H16N2O4 and a molecular weight of 204.22 g/mol, it serves as a critical chiral synthon in the development of complex therapeutic molecules.

Specifications

Industrial Applications

Boc-D-Dap-OH is primarily employed as a high-value intermediate in the pharmaceutical and biotechnology sectors. Its structural features enable precise incorporation into peptide backbones during the synthesis of bioactive compounds, including enzyme inhibitors and receptor modulators. Key application areas include:

• Solid-phase and solution-phase peptide synthesis requiring D-amino acid motifs
• Construction of constrained peptidomimetics for drug discovery programs
• Chiral auxiliary or building block in asymmetric synthesis of advanced organic molecules
• Development of novel neurological therapeutics and complex pharmaceutical APIs

Due to its stability under standard handling conditions and compatibility with Fmoc/Boc orthogonal protection strategies, this intermediate supports scalable and reproducible manufacturing processes.

Handling and Storage

Store at room temperature in a tightly sealed container. Keep in a cool, dry environment away from moisture and direct sunlight. Packaging is typically provided in 25 kg fiber drums, with custom packaging available upon request to meet specific industrial or regulatory requirements.